Journal ArticleDOI
Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation
Sandra Mara A. Arraes,Sandra Mara A. Arraes,Marta S. De Freitas,Marta S. De Freitas,Simone V. da Silva,Simone V. da Silva,Heitor A. Paula Neto,Heitor A. Paula Neto,José C. Alves-Filho,José C. Alves-Filho,Maria Auxiliadora Martins,Maria Auxiliadora Martins,Anibal Basile-Filho,Anibal Basile-Filho,Beatriz Martins Tavares-Murta,Beatriz Martins Tavares-Murta,Christina Barja-Fidalgo,Christina Barja-Fidalgo,Fernando Q. Cunha,Fernando Q. Cunha +19 more
TLDR
Data suggest that endogenous mediators produced during sepsis might continually activate circulating neutrophils, leading to GRK activation, which may induce neutrophil desensitization to chemoattractants.About:
This article is published in Blood.The article was published on 2006-11-01. It has received 141 citations till now. The article focuses on the topics: Impaired neutrophil chemotaxis & Tyrosine phosphorylation.read more
Citations
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Journal ArticleDOI
Vitamin C and Immune Function
Anitra C. Carr,Silvia Maggini +1 more
TL;DR: Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels, and treatment of established infections requires significantly higher doses to compensate for the increased inflammatory response and metabolic demand.
Journal ArticleDOI
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
José C. Alves-Filho,Fabiane Sônego,Fabricio O. Souto,Andressa de Freitas,Waldiceu A. Verri,Maria Auxiliadora-Martins,Anibal Basile-Filho,Andrew Neil James Mckenzie,Damo Xu,Fernando Q. Cunha,Foo Y. Liew +10 more
TL;DR: It is shown that interleukin-33 reduces mortality in mice with experimental sepsis from cecal ligation and puncture (CLP) and reverses the TLR4-induced reduction of CXCR2 expression in neutrophils via the inhibition of expression of G protein–coupled receptor kinase-2 (GRK2), a serine-threonine protein kinase that induces internalization of chemokine receptors.
Journal ArticleDOI
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.
TL;DR: As key regulators of GPCR-dependent and -independent signaling pathways, GRKs are emerging drug targets and promising molecular tools for therapy, and targeted modulation of expression and/or of activity of several GRK isoforms for therapeutic purposes was recently validated in cardiac disorders and Parkinson's disease.
Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
TL;DR: The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.
Journal ArticleDOI
Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
José C. Alves-Filho,Andressa de Freitas,Fabricio O. Souto,Fernando Spiller,Heitor A. Paula-Neto,João Santana da Silva,Ricardo T. Gazzinelli,Mauro M. Teixeira,Sergio H. Ferreira,Fernando Q. Cunha +9 more
TL;DR: The findings identify an unexpected detrimental role of TLR2 in polymicrobial sepsis and suggest that inhibition ofTLR2 signaling may improve survival from septicaemia.
References
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Journal ArticleDOI
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
Journal ArticleDOI
Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee: American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald,WA Knous,J. H. Abrams,G. R. Bernard,JW Biondi,JE Calvin,R Demling,PJ Fahey,CJ Fisher,C Franklin,KJ Gorelick,MA Kelley,DG Maki,JC Marshall,WW Merrill,JP Pribble,EC Rackow,Timothy C. Rodell,JN Sheagren,Michael R. Silver,C. L. Sprung,Richard C. Straube,MJ Tobin,GM Trenholme,DP Wagner,CD Webb,JC Wherry,HP Wiedemann,CH Wortel,M. Kylänpää-Bäck +36 more
Journal ArticleDOI
The immunopathogenesis of sepsis.
TL;DR: Because of the high mortality of sepsis in the face of standard treatment, many efforts have been made to improve understanding of the dysregulation of the host response in sepsi, and much has been learnt of the basic principles governing bacterial–host interactions.
Journal ArticleDOI
Sepsis: A New Hypothesis for Pathogenesis of the Disease Process
Journal ArticleDOI
Chemokines: multiple levels of leukocyte migration control☆ ☆
TL;DR: New insights into the role of chemokines in leukocytes attraction and relocation will be discussed, with emphasis on the distinct levels of leukocyte migration control that ultimately determine the performance of the immune defense system.