M
Martha Zsiga
Researcher at University of Toronto
Publications - 6
Citations - 4396
Martha Zsiga is an academic researcher from University of Toronto. The author has contributed to research in topics: Locus (genetics) & Chromosome 7 (human). The author has an hindex of 4, co-authored 6 publications receiving 4277 citations.
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Journal ArticleDOI
Identification of the cystic fibrosis gene: Chromosome walking and jumping
Johanna M. Rommens,Michael C. Iannuzzi,Batsheva Kerem,Mitchell L. Drumm,Georg Melmer,Michael Dean,Richard Rozmahel,Jeffery L. Cole,Dara Kennedy,Noriko Hidaka,Martha Zsiga,Manuel Buchwald,John R. Riordan,Lap-Chee Tsui,Francis S. Collins +14 more
TL;DR: Several transcribed sequences and conserved segments were identified in this cloned region and one corresponds to the cystic fibrosis gene and spans approximately 250,000 base pairs of genomic DNA.
Journal ArticleDOI
Identification of the cystic fibrosis gene: Chromosome walking and jumping
Johanna M. Rommens,Michael C. Iannuzzi,Batsheva Kerem,Mitchell L. Drumm,Georg Melmer,Michael Dean,Richard Roxmahel,Jeffery L. Cole,Dara Kennedy,Noriko Hidaka,Martha Zsiga,Manuel Buchwald,John R. Riordan,Lap-Chee Tsui,Francis S. Collins +14 more
TL;DR: Several transcribed sequences and conserved segments were identified in this cloned region and one corresponds to the cystic fibrosis gene and spans approximately 250,000 base pairs of genomic DNA.
Journal ArticleDOI
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker
Lap-Chee Tsui,Manuel Buchwald,D. Barker,Jeffrey C. Braman,Robert G. Knowlton,James W. Schumm,Hans Eiberg,Jan Mohr,Dara Kennedy,Natasa Plavsic,Martha Zsiga,Danuta Markiewicz,Gita Akots,Valerie K. Brown,Cynthia Helms,Thomas C. Gravius,Carol A. Parker,Kenneth S. Rediker,Helen Donis-Keller +18 more
TL;DR: The discovery of a linked DNA polymorphism is the first step in molecular analysis of the CF gene and its causative role in the disease.
Journal Article
Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.
Johanna M. Rommens,Zengerling S,Julie E. Burns,Georg Melmer,Batsheva Kerem,Natasa Plavsic,Martha Zsiga,Dara Kennedy,Danuta Markiewicz,Richard Rozmahel,Jack R. Riordan,Manuel Buchwald,Lap-Chee Tsui +12 more
TL;DR: Family and physical mapping studies showed that two of the DNA markers, D7S122 and D7s340, are in close linkage with CF, and reaffirms the general strategy in approaching a disease locus on the basis of chromosome location.