J
Jeffrey C. Braman
Researcher at Harvard University
Publications - 9
Citations - 1813
Jeffrey C. Braman is an academic researcher from Harvard University. The author has contributed to research in topics: Restriction fragment length polymorphism & Genetic linkage. The author has an hindex of 7, co-authored 9 publications receiving 1806 citations.
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A genetic linkage map of the human genome
Helen Donis-Keller,Philip Green,Cynthia Helms,Samuel Cartinhour,Barbara Weiffenbach,Karen Stephens,Tim Keith,Donald W. Bowden,Douglas Smith,Eric S. Lander,David Botstein,Gita Akots,Kenneth S. Rediker,Thomas C. Gravius,Valerie A. Brown,Marcia Rising,Carol A. Parker,Jody A. Powers,Diane E. Watt,Erick R. Kauffman,Angela Bricker,Pamela Phipps,Hans Müller-Kahle,Thomas R. Fulton,Siu Ng,James W. Schumm,Jeffrey C. Braman,Robert G. Knowlton,D. Barker,Steven M. Crooks,Steven E. Lincoln,Mark J. Daly,Jeff Abrahamson +32 more
TL;DR: This work reports the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families, by a combination of mathematical linkage analysis and physical localization of selected clones.
Journal ArticleDOI
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker
Lap-Chee Tsui,Manuel Buchwald,D. Barker,Jeffrey C. Braman,Robert G. Knowlton,James W. Schumm,Hans Eiberg,Jan Mohr,Dara Kennedy,Natasa Plavsic,Martha Zsiga,Danuta Markiewicz,Gita Akots,Valerie K. Brown,Cynthia Helms,Thomas C. Gravius,Carol A. Parker,Kenneth S. Rediker,Helen Donis-Keller +18 more
TL;DR: The discovery of a linked DNA polymorphism is the first step in molecular analysis of the CF gene and its causative role in the disease.
Journal ArticleDOI
A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7
Robert G. Knowlton,Odile Cohen-Haguenauer,Nguyen Van Cong,Jean Frézal,Valerie A. Brown,D. Barker,Jeffrey C. Braman,James W. Schumm,Lap-Chee Tsui,Manuel Buchwald,Helen Donis-Keller +10 more
TL;DR: It is reported here that the genetic locus DOCRI-917 defined by the cloned DNA probe is located on chromosome 7, which is among the most common inherited diseases in Caucasian populations.
Journal ArticleDOI
Use of Highly Polymorphic DNA Probes for Genotypic Analysis Following Bone Marrow Transplantation
Robert G. Knowlton,Valerie A. Brown,Jeffrey C. Braman,David F. Barker,James W. Schumm,Christine Murray,Tak Takvorian,Jerome Ritz,Helen Donis-Keller +8 more
TL;DR: A set of DNA probes isolated from highly polymorphic loci by which siblings can usually be distinguished are applied to the analysis of cells from peripheral blood and bone marrow after transplantation and demonstrated their usefulness in confirming engraftment of donor cells or graft rejection, and in detecting mixed lympho-hematopoietic chimerism.
Journal Article
Identification of more than 500 RFLPs by screening random genomic clones.
J W Schumm,R G Knowlton,Jeffrey C. Braman,D. Barker,David Botstein,Gita Akots,V A Brown,Thomas C. Gravius,Cynthia Helms,K Hsiao +9 more
TL;DR: A large-scale screening study to identify RFLPs useful as genetic markers found restriction enzymes MspI, TaqI, and RsaI were most efficient in detecting polymorphism within the 1-20-kb-fragment size range resolved.