M
Martin E. Fernandez-Zapico
Researcher at Mayo Clinic
Publications - 231
Citations - 14148
Martin E. Fernandez-Zapico is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Pancreatic cancer & Transcription factor. The author has an hindex of 47, co-authored 205 publications receiving 12174 citations. Previous affiliations of Martin E. Fernandez-Zapico include University of Saint Mary & McGill University.
Papers
More filters
Journal ArticleDOI
LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth.
TL;DR: This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.
Journal ArticleDOI
IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Mihir Rajurkar,Kyvan Dang,Maite G. Fernandez-Barrena,Xiangfan Liu,Martin E. Fernandez-Zapico,Brian C. Lewis,Junhao Mao +6 more
TL;DR: It is shown that the noncanonical IκB-related kinase, I KBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation and combined inhibition of IKBKE and mTOR synergistically blocks pancreatic tumor growth.
Journal ArticleDOI
Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells
Leah E. Colvin Wanshura,Katherine E. Galvin,Hong Ye,Martin E. Fernandez-Zapico,Cynthia Wetmore +4 more
TL;DR: It is reported that the transcription factor and oncogene Snail1 (Sna1) is directly induced by Shh pathway activity in GCPs, murine medulloblastomas, and human medullOBlastoma cells and that depletion of N-Myc ablated the Sna1-induced proliferation and transformation.
Journal ArticleDOI
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas.
Elizabeth Lenkiewicz,Smriti Malasi,Tara L. Hogenson,Luis F. Flores,Whitney Barham,William J. Phillips,Alexander S. Roesler,Kendall Chambers,Nirakar Rajbhandari,Akimasa Hayashi,Corina E. Antal,Michael Downes,Paul M. Grandgenett,Michael A. Hollingsworth,Derek Cridebring,Yuning Xiong,Jeong Heon Lee,Zhenqing Ye,Huihuang Yan,Matthew C. Hernandez,Jennifer L. Leiting,Ronald M. Evans,Tamas Ordog,Mark J. Truty,Mitesh J. Borad,Tannishtha Reya,Daniel D. Von Hoff,Martin E. Fernandez-Zapico,Michael T. Barrett +28 more
TL;DR: The results suggest that the genomic and epigenomic landscape of ASCP provide new strategies for targeting this aggressive subtype of pancreatic cancer.
Journal ArticleDOI
Role for Krüppel-Like Transcription Factor 11 in Mesenchymal Cell Function and Fibrosis
Angela Mathison,Adrienne Grzenda,Gwen Lomberk,Gabriel Velez,Navtej S. Buttar,Pamela S. Tietz,Helen Hendrickson,Ann Liebl,Yuning Y. Xiong,Gregory J. Gores,Martin E. Fernandez-Zapico,Nicholas F. LaRusso,William A. Faubion,Vijay H. Shah,Raul Urrutia +14 more
TL;DR: KLF11 expands the repertoire of transcription factors involved in the regulation of extracellular matrix proteins in mesenchymal cells and defines a novel pathway that modulates the fibrogenic response during liver injury.