J
Junhao Mao
Researcher at University of Massachusetts Medical School
Publications - 65
Citations - 8546
Junhao Mao is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Wnt signaling pathway & Hedgehog. The author has an hindex of 34, co-authored 58 publications receiving 7741 citations. Previous affiliations of Junhao Mao include Harvard University & National Institute of Chemical Physics and Biophysics.
Papers
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Journal ArticleDOI
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Lynn M. Boyden,Junhao Mao,Joseph L. Belsky,Lyle Mitzner,Anita Farhi,Mary Ann Mitnick,Dianqing Wu,Karl L. Insogna,Richard P. Lifton +8 more
TL;DR: The LRP5V171 mutation causes high bone density, with a thickened mandible and torus palatinus, by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling.
Journal ArticleDOI
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.
Junhao Mao,Junhao Mao,Jiyong Wang,Bo Liu,Bo Liu,Weijun Pan,Gist H. Farr,Christopher Flynn,Huidong Yuan,Shinji Takada,David Kimelman,Lin Li,Dianqing Wu +12 more
TL;DR: It is concluded that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway, and the L RP-5 sequences involved in interactions with Axin are required for LEF-1 activation.
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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Ulrich Schüller,Vivi M. Heine,Vivi M. Heine,Junhao Mao,Alvin T. Kho,Allison K. Dillon,Young-Goo Han,Emmanuelle Huillard,Emmanuelle Huillard,Tao Sun,Azra H. Ligon,Azra H. Ligon,Ying Qian,Qiufu Ma,Arturo Alvarez-Buylla,Andrew P. McMahon,David H. Rowitch,Keith L. Ligon +17 more
TL;DR: It is shown in human and mouse medulloblastoma that cells expressing the glia-associated markers Gfap and Olig2 are neoplastic and retain features of embryonic-type granule lineage progenitors, indicating that acquisition of CGNP identity is essential for tumorigenesis.
Journal ArticleDOI
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
TL;DR: It is demonstrated that Hh signaling in NCCs is essential for normal patterning and growth of the face, and the analysis of Shh-Fox gene regulatory interactions leads to propose that Fox genes mediate the action of ShH in facial development.
Journal ArticleDOI
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
Lin Li,Huidong Yuan,Carole D. Weaver,Junhao Mao,Gist H. Farr,Daniel J. Sussman,Jos Jonkers,David Kimelman,Dianqing Wu +8 more
TL;DR: The observation that the Dvl‐binding domain of either Frat1 or Axin was able to inhibit Wnt‐1‐induced LEF‐1 activation suggests that the interactions between Dvl and Axin and between DVL and Frat may be important for this signaling pathway.