Martin Fugère

TL;DR: It is concluded that furin, in addition to other candidate PCs, is involved in TACE maturation and activation.

TL;DR: In this paper, the authors designed specific nanomolar inhibitors of PC modeled from the extended cleavage motif TPQRERRRKKR downward arrow of the avian influenza H5N1 hemagglutinin.

TL;DR: Studies of unprocessed virus produced in FD11 cells (wt/p62) demonstrated that the p62 protein was efficiently cleaved by purified furin in vitro, without requiring prior exposure to low pH.

TL;DR: This study investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7, and demonstrated that the use of proDomains as specific inhibitors acting in trans would be of limited usefulness, unless modified into more specific compounds.

TL;DR: It is concluded that basic residues within PC peptide inhibitors might be responsible for targeting PCs in general and for inhibitory potency, but that select amino acid changes will be necessary to acquire true specificity toward a single PC.