M
Martin Hemberg
Researcher at Wellcome Trust Sanger Institute
Publications - 125
Citations - 13581
Martin Hemberg is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 37, co-authored 102 publications receiving 10274 citations. Previous affiliations of Martin Hemberg include Boston Children's Hospital & Wellcome Trust/Cancer Research UK Gurdon Institute.
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Discrete Distributional Differential Expression (D3E) - A Tool for Gene Expression Analysis of Single-cell RNA-seq Data
Mihails Delmans,Martin Hemberg +1 more
TL;DR: This work presents a discrete, distributional method for differential gene expression (D3E), a novel algorithm specifically designed for single-cell RNA-seq data, and uses D3E to investigate experimental data and test hypotheses about the driving mechanism behind changes in gene expression.
Posted ContentDOI
souporcell: Robust clustering of single cell RNAseq by genotype and ambient RNA inference without reference genotypes
Haynes Heaton,Arthur M. Talman,Andrew J Knights,Maria Imaz,Maria Imaz,Daniel J. Gaffney,Richard Durbin,Martin Hemberg,Mara K. N. Lawniczak +8 more
TL;DR: Souporcell is a novel method to cluster cells using only the genetic variants detected within the scRNAseq reads that achieves high accuracy on genotype clustering, doublet detection, and ambient RNA estimation as demonstrated across a wide range of challenging scenarios.
Journal ArticleDOI
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
Ilias Georgakopoulos-Soares,Ilias Georgakopoulos-Soares,Gene Koh,Gene Koh,Sophie Momen,Josef Jiricny,Martin Hemberg,Serena Nik-Zainal +7 more
TL;DR: A method is described to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletions, including transcription-coupled nucleotide excision repair (TC-NER).
Journal ArticleDOI
High-throughput characterization of the role of non-B DNA motifs on promoter function
Ilias Georgakopoulos-Soares,Jesus Victorino,Guillermo E. Parada,Vikram Agarwal,Jingjing Zhao,Hei Yuen Wong,Mubarak I. Umar,O. Elor,Allan Muhwezi,Joon Yong An,Stephen Sanders,Chun Kit Kwok,Fumitaka Inoue,Martin Hemberg,Nadav Ahituv +14 more
TL;DR: In this article , the authors used computational genomic analyses coupled with massively parallel reporter assays (MPRAs) to show that certain non-B DNA structures have a substantial effect on gene expression.
Posted ContentDOI
The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete Plasmodium life cycle
Virginia M. Howick,Andrew Russell,Tallulah S. Andrews,Haynes Heaton,Adam J. Reid,Kedar Nath Natarajan,Hellen Butungi,Tom Metcalf,Lisa H. Verzier,Julian C. Rayner,Matthew Berriman,Jeremy K. Herren,Oliver Billker,Oliver Billker,Martin Hemberg,Arthur M. Talman,Mara K. N. Lawniczak +16 more
TL;DR: This work profiles the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle, and defines developmental stages of single cells from three different human malaria parasite species.