M
Martin Kreitman
Researcher at University of Chicago
Publications - 111
Citations - 18245
Martin Kreitman is an academic researcher from University of Chicago. The author has contributed to research in topics: Locus (genetics) & Gene. The author has an hindex of 58, co-authored 111 publications receiving 17587 citations. Previous affiliations of Martin Kreitman include Princeton University & National Institutes of Health.
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Journal ArticleDOI
Adaptive protein evolution at the Adh locus in Drosophila
John H. McDonald,Martin Kreitman +1 more
TL;DR: A simple statistical test of the neutral protein evolution hypothesis is proposed based on a comparison of the number of amino-acid replacement substitutions to synonymous substitutions in the coding region of a locus, finding that there are more fixed replacement differences between species than expected.
Journal ArticleDOI
A Test of Neutral Molecular Evolution Based on Nucleotide Data
TL;DR: A conservative statistical test of the neutral theory of molecular evolution's prediction that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species is presented.
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The pattern of polymorphism in Arabidopsis thaliana.
Magnus Nordborg,Tina T. Hu,Yoko Ishino,Jinal Jhaveri,Christopher Toomajian,Honggang Zheng,E. G. Bakker,Peter Calabrese,Jean Gladstone,Rana Goyal,Mattias Jakobsson,Sung K. Kim,Yuri Morozov,Badri Padhukasahasram,Vincent Plagnol,Noah A. Rosenberg,Chitiksha Shah,Jeffrey D. Wall,Jue Wang,Keyan Zhao,Theodore S. Kalbfleisch,Vincent P. Schulz,Martin Kreitman,Joy Bergelson +23 more
TL;DR: The data support the utility of A. thaliana as a model for evolutionary functional genomics and suggest there is a genome-wide excess of rare alleles and too much variation between genomic regions in the level of polymorphism.
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Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana.
TL;DR: Results of a field experiment comparing the fitness of isogenic strains that differ in the presence or absence of RPM1 and its natural promoter reveal a large cost ofrpm1, providing the first evidence that costs contribute to the maintenance of an ancient R-gene polymorphism.
Journal ArticleDOI
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
TL;DR: The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms, but only one of the 43 polymorphisms results in an amino acid change.