Vincent P. Schulz

TL;DR: The data support the utility of A. thaliana as a model for evolutionary functional genomics and suggest there is a genome-wide excess of rare alleles and too much variation between genomic regions in the level of polymorphism.

TL;DR: Pairs of SNPs exhibited variability in the degree of linkage disequilibrium that was a function of their location within a gene, distance from each other, population distribution, and population frequency.

TL;DR: Findings, the first report of mutation in a mammalian mechanosensory transduction channel-associated with genetic disease, suggest that PIEZO proteins play an important role in maintaining erythrocyte volume homeostasis.

TL;DR: Clustering and network analyses revealed that varying stage-specific patterns of expression observed across differentiation were enriched for genes of differing function, and tight clustering of transcriptomes from differing stages, even between biologically different replicates, validated the utility of the FACS-based assays.

TL;DR: The data demonstrate that the stochastic nature of reprogramming can be overcome in a privileged somatic cell state and suggest that cell-cycle acceleration toward a critical threshold is an important bottleneck for reprograming.