T
Theodore S. Kalbfleisch
Researcher at University of Louisville
Publications - 52
Citations - 7830
Theodore S. Kalbfleisch is an academic researcher from University of Louisville. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 20, co-authored 44 publications receiving 7474 citations.
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Journal ArticleDOI
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Peter Uetz,Loic Giot,Gerard Cagney,Traci A. Mansfield,Richard S. Judson,James R. Knight,Daniel Lockshon,Vaibhav A. Narayan,Maithreyan Srinivasan,Pascale Pochart,Alia Qureshi-Emili,Ying Li,Brian C. Godwin,Diana Conover,Theodore S. Kalbfleisch,Govindan Vijayadamodar,Meijia Yang,Mark Johnston,Stanley Fields,Jonathan M. Rothberg +19 more
TL;DR: Examination of large-scale yeast two-hybrid screens reveals interactions that place functionally unclassified proteins in a biological context, interactions between proteins involved in the same biological function, and interactions that link biological functions together into larger cellular processes.
Journal ArticleDOI
The pattern of polymorphism in Arabidopsis thaliana.
Magnus Nordborg,Tina T. Hu,Yoko Ishino,Jinal Jhaveri,Christopher Toomajian,Honggang Zheng,E. G. Bakker,Peter Calabrese,Jean Gladstone,Rana Goyal,Mattias Jakobsson,Sung K. Kim,Yuri Morozov,Badri Padhukasahasram,Vincent Plagnol,Noah A. Rosenberg,Chitiksha Shah,Jeffrey D. Wall,Jue Wang,Keyan Zhao,Theodore S. Kalbfleisch,Vincent P. Schulz,Martin Kreitman,Joy Bergelson +23 more
TL;DR: The data support the utility of A. thaliana as a model for evolutionary functional genomics and suggest there is a genome-wide excess of rare alleles and too much variation between genomic regions in the level of polymorphism.
Journal ArticleDOI
Haplotype variation and linkage disequilibrium in 313 human genes.
J. Claiborne Stephens,Julie A. Schneider,Debra A. Tanguay,Julie . Choi,Tara Acharya,Scott E. Stanley,Ruhong Jiang,Chad Messer,Anne Chew,Jin-Hua Han,Jicheng Duan,Janet L. Carr,Min Seob Lee,Beena Koshy,A. Madan Kumar,Ge Zhang,William R. Newell,Andreas Windemuth,Chuanbo Xu,Theodore S. Kalbfleisch,Sandra L. Shaner,Kevin M. Arnold,Vincent P. Schulz,Connie M. Drysdale,Krishnan Nandabalan,Richard S. Judson,Gualberto Ruaño,Gerald F. Vovis +27 more
TL;DR: Pairs of SNPs exhibited variability in the degree of linkage disequilibrium that was a function of their location within a gene, distance from each other, population distribution, and population frequency.
Journal ArticleDOI
Improved reference genome for the domestic horse increases assembly contiguity and composition
Theodore S. Kalbfleisch,Edward S. Rice,Michael S. DePriest,Brian P. Walenz,Matthew S. Hestand,Joris Vermeesch,Brendan L. O′Connell,Brendan L. O′Connell,Ian T. Fiddes,Alisa O. Vershinina,Nedda F. Saremi,Jessica L. Petersen,Carrie J. Finno,Rebecca R. Bellone,Molly E. McCue,Samantha A. Brooks,Ernest Bailey,Ludovic Orlando,Ludovic Orlando,Richard E. Green,Donald Miller,Douglas F. Antczak,James N. MacLeod +22 more
TL;DR: An improved genome assembly for the domestic horse is presented by combining short- and long-read data, as well as proximity ligation data, which improves contiguity of the assembly by 40-fold, with a 10-fold reduction in gaps.
Journal ArticleDOI
SNPs for Parentage Testing and Traceability in Globally Diverse Breeds of Sheep
Michael P. Heaton,Kreg A. Leymaster,Theodore S. Kalbfleisch,James Kijas,Shannon M. Clarke,John C. McEwan,Jillian F. Maddox,Veronica Basnayake,Dustin T. Petrik,Barry Simpson,Timothy P. L. Smith,Carol G. Chitko-McKown +11 more
TL;DR: The availability of a well-characterized set of 163 parentage SNPs facilitates the development of high-throughput genetic technologies for implementing accurate and economical parentage testing and traceability in many of the world’s sheep breeds.