M
Martin Lotz
Researcher at Scripps Research Institute
Publications - 382
Citations - 33862
Martin Lotz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 97, co-authored 343 publications receiving 30942 citations. Previous affiliations of Martin Lotz include Japan Agency for Medical Research and Development & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
Regulation of YKL-40 production by human articular chondrocytes.
TL;DR: The spontaneous increase in the production of YKL-40 in the early phase of culture appears to represent a cellular response to changes in the extracellular matrix environment.
Journal ArticleDOI
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site.
TL;DR: Results reveal novel mechanisms by which Notch signaling represses gene expression and prevent SOX9-mediated transcriptional activation of COL2A1 and, thus, chondrogenic differentiation.
Journal ArticleDOI
Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis
Hidetsugu Suzuki,Yoshiaki Ito,Masahiro Shinohara,Satoshi Yamashita,Shizuko Ichinose,Akio Kishida,Takuya Oyaizu,Tomohiro Kayama,Ryo Nakamichi,Naoki Koda,Kazuyoshi Yagishita,Martin Lotz,Atsushi Okawa,Hiroshi Asahara +13 more
TL;DR: It is demonstrated that Mkx has a dual role, including accelerating tendon differentiation and preventing chondrogenic/osteogenic differentiation, and this molecular network of Mkx provides a basis for tendon physiology and tissue engineering.
Journal ArticleDOI
Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis
TL;DR: The specific stimulation of synoviocytes by the neuropeptide substance P represents a pathway by which the nervous system might be directly involved in the pathogenesis of rheumatoid arthritis.
Journal ArticleDOI
Glucosamine Activates Autophagy In Vitro and In Vivo
Beatriz Caramés,William B. Kiosses,Yukio Akasaki,Diana C. Brinson,William Eap,James A. Koziol,Martin Lotz +6 more
TL;DR: It is suggested that glucosamines is an effective autophagy activator and should motivate future studies on the efficacy of glucosamine in modifying aging-related cellular changes and supporting joint health.