M
Martin Lotz
Researcher at Scripps Research Institute
Publications - 382
Citations - 33862
Martin Lotz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 97, co-authored 343 publications receiving 30942 citations. Previous affiliations of Martin Lotz include Japan Agency for Medical Research and Development & University of California, San Diego.
Papers
More filters
Journal Article
Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes.
TL;DR: The results show that PCNA expression is regulated by a signal after IL 2 binding and thatPCNA labeling is a precise indicator for human T cells that are committed to DNA synthesis.
Journal ArticleDOI
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs
Ryo Nakamichi,Yoshiaki Ito,Masafumi Inui,Naoko Onizuka,Tomohiro Kayama,Kensuke Kataoka,Hidetsugu Suzuki,Masaki Mori,Masayo Inagawa,Shizuko Ichinose,Martin Lotz,Daisuke Sakai,Koichi Masuda,Toshifumi Ozaki,Hiroshi Asahara +14 more
TL;DR: It is shown that homeobox protein Mohawk (Mkx) is a key transcription factor that regulates AF development, maintenance and regeneration and that Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model.
Journal ArticleDOI
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
U. Nogueira-Recalde,I. Lorenzo-Gomez,Francisco J. Blanco,María Isabel Loza,Diego Grassi,V. Shirinsky,Ivan Shirinsky,Martin Lotz,Paul D. Robbins,Eduardo Domínguez,Beatriz Caramés +10 more
TL;DR: FN, a PPARα agonist used for dyslipidaemias in humans, reduced the number of senescent cells via apoptosis, increased autophagic flux, and protected against cartilage degradation in both ageing human and OA chondrocytes.
Journal ArticleDOI
Expression of prepro-enkephalin in human articular chondrocytes is linked to cell proliferation.
Peter M. Villiger,Martin Lotz +1 more
TL;DR: In this article, it was shown that cultured human articular chondrocytes express high levels of 1.4 kb prepro-enkephalin mRNA, but not in confluent, contact-inhibited cells.
Journal ArticleDOI
Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment.
TL;DR: It is demonstrated that FN-f induced nitric oxide (NO) production from human articular chondrocytes and the effect of IL-1 receptor antagonist (IL-1ra) and mitogen-activated protein kinases showed activation of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase, and p38 MAPK.