M
Martin R. Saunders
Researcher at GlaxoSmithKline
Publications - 5
Citations - 997
Martin R. Saunders is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: RNase P & Topoisomerase. The author has an hindex of 4, co-authored 5 publications receiving 862 citations.
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Journal ArticleDOI
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Benjamin D. Bax,Pan F. Chan,Drake S. Eggleston,Drake S. Eggleston,Andrew P. Fosberry,Daniel R. Gentry,Fabrice Gorrec,Fabrice Gorrec,Ilaria Giordano,Michael M. Hann,Alan Joseph Hennessy,Martin Hibbs,Jianzhong Huang,Emma J. Jones,Jo J. Jones,Kristin K. Brown,Ceri J. Lewis,Earl May,Earl May,Martin R. Saunders,Onkar M. P. Singh,Claus Spitzfaden,Carol Shen,Anthony Shillings,Andrew J. Theobald,Alexandre Wohlkonig,Alexandre Wohlkonig,Neil D. Pearson,Michael N. Gwynn +28 more
TL;DR: This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class.
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Glycoforms modify the dynamic stability and functional activity of an enzyme.
Pauline M. Rudd,Heidi C. Joao,Eva Coghill,Pierre Fiten,Martin R. Saunders,Ghislain Opdenakker,Raymond A. Dwek +6 more
TL;DR: Consistent with the overall decrease in flexibility, and with the possibility that all of the sugars may afford steric protection to susceptible sites, was the finding that each of the glycoforms tested showed increased resistance to Pronase compared with the unglycosylated protein.
Journal ArticleDOI
Orientation of the headgroup of phosphatidylinositol in a model biomembrane as determined by neutron diffraction
TL;DR: Comparison of the neutron diffraction scattering profiles for deuterated and undeuterated membranes allowed the orientation of the inositol ring which lies more-or-less along the bilayer normal projecting directly out into the water to be determined to be similar to that of the sugar residue in glycolipids.
Journal ArticleDOI
Theoretical and experimental investigations on the morphology of pharmaceutical crystals.
TL;DR: This work investigated the morphologies of three polymorphs of 1,3-di(cyclopropylmethyl)-8-aminoxanthine, a compound of pharmaceutical importance, and compared the experimental morphologies with those predicted by theoretical methods.