M
Martin Ridderstråle
Researcher at Lund University
Publications - 124
Citations - 22978
Martin Ridderstråle is an academic researcher from Lund University. The author has contributed to research in topics: Type 2 diabetes & Insulin. The author has an hindex of 35, co-authored 120 publications receiving 20479 citations. Previous affiliations of Martin Ridderstråle include Steno Diabetes Center & Scania AB.
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Journal ArticleDOI
Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
TL;DR: It is concluded that FOXC2 is associated with obesity and metabolic deterioration but does not contribute to an increased risk for type 2 diabetes.
Journal ArticleDOI
Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals.
E Suviolahti,Martin Ridderstråle,Peter Almgren,Mia Klannemark,Olle Melander,Emma Carlsson,M Carlsson,Jan Hedenbro,Marju Orho-Melander +8 more
TL;DR: Polymorphisms in POMC are associated with variation in serum leptin levels within the normal range in healthy lean but not in obese individuals, and neither the C8246T CC-genotype nor the C 8246T(CC)/RsaI(−−or +−) genotype combinations were associated with serumptin levels in obese subjects.
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Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes.
TL;DR: The role for JAK2 in mediating the insulin-like effects of GH in adipocytes is supported, with screening a number of tyrosine kinase inhibitors finding only staurosporine was found to inhibit all three effects.
Journal ArticleDOI
Estimating the impact of changes in HbA 1c , body weight and insulin injection regimen on health related quality-of-life: a time trade off study
Martin Ridderstråle,L. M. Evans,Henrik Holm Jensen,Mette Bøgelund,Marie Markert Jensen,Åsa Ericsson,Johan Jendle +6 more
TL;DR: Changes in HbA1c levels, insulin regimen and body weight are all likely to affect HRQoL for patients with T2D, and a treatment which has a simple regimen with fewer injections, and/or the need for less planning, and that causes weight loss or less weight gain will have a positive impact on HRQeL.
Journal ArticleDOI
Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
TL;DR: TCF7L2 mRNA levels in adipocytes are decreased by insulin and seem to increase in insulin resistant subjects and in HapA carriers, and when stratifying for haplotype, this difference was seen in HAPA carriers but not in non-HapA carrier.