M
Martin Röcken
Researcher at Ludwig Maximilian University of Munich
Publications - 80
Citations - 3561
Martin Röcken is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 25, co-authored 80 publications receiving 3452 citations. Previous affiliations of Martin Röcken include University of Tübingen & National Institutes of Health.
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Journal ArticleDOI
Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
Kamran Ghoreschi,Peter Thomas,Susanne Breit,Martin Dugas,Reinhard Mailhammer,Willem van Eden,Ruurd van der Zee,Tilo Biedermann,Jörg C. Prinz,Matthias Mack,Ulrich Mrowietz,Enno Christophers,Detlef Schlöndorff,Gerd Plewig,Christian A. Sander,Martin Röcken,Martin Röcken +16 more
TL;DR: IL-4 therapy can induce Th2 differentiation in human CD4+ T cells and has promise as a potential treatment for psoriasis, a prototypic Th1-associated autoimmune disease.
Journal ArticleDOI
Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2
Tilo Biedermann,Manfred Kneilling,Reinhard Mailhammer,K.L. Maier,Christian A. Sander,George Kollias,Steven L. Kunkel,Lothar Hültner,Martin Röcken +8 more
TL;DR: Analysis of hapten-induced DTHRs of the skin found that mast cells determine the T cell–dependent PMN recruitment through two mediators, tumor necrosis factor (TNF) and the CXC chemokine macrophage inflammatory protein 2 (MIP-2), the functional analogue of human interleukin 8.
Journal ArticleDOI
Natural Killer Cells Activated by MHC Class ILow Targets Prime Dendritic Cells to Induce Protective CD8 T Cell Responses
Ralph Mocikat,Heidi Braumüller,Heidi Braumüller,Alain Gumy,Oliver Egeter,Heike Ziegler,Uwe Reusch,Anja Bubeck,Jacques A. Louis,Reinhard Mailhammer,Gert Riethmüller,Ulrich H. Koszinowski,Martin Röcken,Martin Röcken +13 more
TL;DR: It is shown that MHC class I(low) targets initiate a cascade of immune responses, starting with the immediate activation of NK cells, which can link innate and adaptive immunity to induce protective T cell responses and may alarm the immune system during early infection with noncytopathic viruses.
Journal ArticleDOI
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.
Tilo Biedermann,Stephan Zimmermann,Stephan Zimmermann,Hayo Himmelrich,Alain Gumy,Oliver Egeter,Arne Klaus Sakrauski,Irene Seegmüller,Heike Voigt,Pascal Launois,Pascal Launois,Alan D. Levine,Hermann Wagner,Klaus Heeg,Klaus Heeg,Jacques A. Louis,Martin Röcken +16 more
TL;DR: It is shown that when present during the initial activation of dendritic cells by infectious agents, IL-4 instructed DCs to produce IL-12 and promote TH1 development, which established resistance to Leishmania major in susceptible BALB/c mice.
Journal ArticleDOI
IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
TL;DR: The experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.