R
Ralph Mocikat
Researcher at Technische Universität München
Publications - 43
Citations - 2634
Ralph Mocikat is an academic researcher from Technische Universität München. The author has contributed to research in topics: Immunotherapy & Immune system. The author has an hindex of 20, co-authored 43 publications receiving 2297 citations. Previous affiliations of Ralph Mocikat include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
T-helper-1-cell cytokines drive cancer into senescence
Heidi Braumüller,Thomas Wieder,Ellen Brenner,Sonja Aßmann,Matthias Hahn,Mohammed Alkhaled,Karin Schilbach,Frank Essmann,Manfred Kneilling,Christoph M. Griessinger,Felicia Ranta,Susanne Ullrich,Ralph Mocikat,Kilian Braungart,Tarun Mehra,Birgit Fehrenbacher,Julia Berdel,Heike Niessner,Friedegund Meier,Maries van den Broek,Hans-Ulrich Häring,Rupert Handgretinger,Leticia Quintanilla-Martinez,Falko Fend,Marina Pesic,Jürgen Bauer,Lars Zender,Martin Schaller,Klaus Schulze-Osthoff,Martin Röcken +29 more
TL;DR: The combined action of the T-helper-1-cell cytokines IFN-γ and tumour necrosis factor (TNF) directly induces permanent growth arrest in cancers, a general mechanism for arresting cancer progression.
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Natural Killer Cells Activated by MHC Class ILow Targets Prime Dendritic Cells to Induce Protective CD8 T Cell Responses
Ralph Mocikat,Heidi Braumüller,Heidi Braumüller,Alain Gumy,Oliver Egeter,Heike Ziegler,Uwe Reusch,Anja Bubeck,Jacques A. Louis,Reinhard Mailhammer,Gert Riethmüller,Ulrich H. Koszinowski,Martin Röcken,Martin Röcken +13 more
TL;DR: It is shown that MHC class I(low) targets initiate a cascade of immune responses, starting with the immediate activation of NK cells, which can link innate and adaptive immunity to induce protective T cell responses and may alarm the immune system during early infection with noncytopathic viruses.
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TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis.
Nele Müller-Hermelink,Heidi Braumüller,Bernd J. Pichler,Thomas Wieder,Reinhard Mailhammer,Katrin Schaak,Kamran Ghoreschi,Amir S. Yazdi,Roland Haubner,Christian Sander,Ralph Mocikat,Markus Schwaiger,Irmgard Förster,Ralph Huss,Wolfgang Weber,Manfred Kneilling,Martin Röcken +16 more
TL;DR: Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets shows that tumor-specific T cells home selectively into the tumor microenvironment around the islets, where they either arrest or promote transition of dysplastic islets into islet carcinomas.
Journal Article
Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies.
TL;DR: It is found that fusion of rat with mouse hybridomas opens the possibility of large scale production of bispecific Ab due to the increased incidence of correctly paired Ab and facilitated purification.
Journal Article
Eradication of Disseminated Lymphomas with CpG-DNA Activated T Helper Type 1 Cells from Nontransgenic Mice
TL;DR: In this article, a single injection of 0.5 x 10(6) A20-specific Th1 cells even eradicated disseminated A20 lymphomas and provided lifelong protection without inducing autoimmune disease.