M
Martin S. Weber
Researcher at Technische Universität München
Publications - 55
Citations - 3506
Martin S. Weber is an academic researcher from Technische Universität München. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis. The author has an hindex of 25, co-authored 55 publications receiving 3163 citations. Previous affiliations of Martin S. Weber include Max Planck Society & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease
Martin S. Weber,Thomas Prod'homme,Sawsan Youssef,Shannon E. Dunn,Cynthia D Rundle,Linda Lee,Juan C. Patarroyo,Olaf Stüve,Raymond A. Sobel,Lawrence Steinman,Scott S. Zamvil +10 more
TL;DR: Adoptive transfer of type II monocytes reversed EAE, suppressed TH17 cell development and promoted both TH2 differentiation and expansion of Treg cells in recipient mice, identifying a central role for these cells in T cell immune modulation of autoimmunity.
Journal ArticleDOI
MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
Nicolas Molnarfi,Ulf Schulze-Topphoff,Martin S. Weber,Juan C. Patarroyo,Thomas Prod'homme,Michel Varrin-Doyer,Aparna Shetty,Christopher Linington,Anthony J. Slavin,Juan Hidalgo,Dieter E. Jenne,Hartmut Wekerle,Raymond A. Sobel,Claude C.A. Bernard,Mark J. Shlomchik,Scott S. Zamvil +15 more
TL;DR: Antigen presentation, but not antibody secretion, by B cells drives CNS autoimmunity induced by immunization with human MOG.
Journal ArticleDOI
B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.
Martin S. Weber,Thomas Prod'homme,Juan C. Patarroyo,Nicolas Molnarfi,Tara Karnezis,Klaus Lehmann-Horn,Dimitry M. Danilenko,Jeffrey Eastham-Anderson,Anthony J. Slavin,Christopher Linington,Claude C.A. Bernard,Flavius Martin,Scott S. Zamvil +12 more
TL;DR: Clinical studies indicate that anti‐CD20 B‐cell depletion may be an effective multiple sclerosis therapy and mechanisms of anti-CD20‐mediated immune modulation using 2 paradigms of experimental autoimmune encephalomyelitis (EAE) are investigated.
Journal ArticleDOI
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.
Shannon E. Dunn,Sawsan Youssef,Matthew J. Goldstein,Thomas Prod'homme,Martin S. Weber,Scott S. Zamvil,Lawrence Steinman +6 more
TL;DR: By connecting isoprenoid availability to regulation of Th1/Th2 fate, AT has elucidated a mechanism by which AT may suppress Th1-mediated central nervous system autoimmune disease.
Journal ArticleDOI
CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
Markus C. Kowarik,Sabine Cepok,Johann Sellner,Verena Grummel,Martin S. Weber,Thomas Korn,Achim Berthele,Bernhard Hemmer +7 more
TL;DR: Elevated CSF CXCL13 levels rather reflect a strong humoral immune response in the CNS compartment than being specific for a particular disease entity, and seems to be the major determinant for B cell recruitment to the central nervous system compartment in different neuroinflammatory diseases.