M
Martina Deseyve
Researcher at Fred Hutchinson Cancer Research Center
Publications - 5
Citations - 2998
Martina Deseyve is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Nevirapine & Regimen. The author has an hindex of 5, co-authored 5 publications receiving 2967 citations. Previous affiliations of Martina Deseyve include Johns Hopkins University.
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial
J. Brooks Jackson,Philippa Musoke,Thomas Fleming,Thomas Fleming,Laura Guay,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Maxensia Owor,Constance Ducar,Martina Deseyve,Anthony Mwatha,Lynda Emel,Corey Duefield,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Maria Gigliotti,Dorothy Bray,Francis Mmiro +22 more
TL;DR: Intrapartum/ne ononatal nevirapine significantly lowered HIV-1 transmission risk in a breastfeeding population in Uganda compared with a short intrapartu/neonatal zidovudine regimen.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow up of the HIVNET 012 randomized trial
J. Brooks Jackson,Philippa Musoke,Tom P. Fleming,Laura Guay,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M. Bakaki,Maxensia Owor,Contance Ducar,Martina Deseyve,Anthony Mwatha,Lynda Emel,Corey Duefield,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Maria Gigllottl,Dorothy Bray,Francis Mmiro +21 more
TL;DR: Intrapartum/neonatal nevirapine appears to be a simple, inexpensive, and well-tolerated regimen for significantly reducing perinatal transmission of HIV-1 in less developed countries.
Journal ArticleDOI
Impact of Human Immunodeficiency Virus Type 1 (HIV-1) Subtype on Women Receiving Single-Dose Nevirapine Prophylaxis to Prevent HIV-1 Vertical Transmission (HIV Network for Prevention Trials 012 Study)
Susan H. Eshleman,Graziella Becker-Pergola,Martina Deseyve,Laura Guay,Martin Mracna,Thomas Fleming,Thomas Fleming,Shawn Cunningham,Philippa Musoke,Francis Mmiro,J. Brooks Jackson +10 more
TL;DR: Examination of the relationship between HIV-1 subtype, MTCT, and the development of Nvp resistance (Nvp(R) among women enrolled in HIVNET 012 finds no apparent difference in the rate of MTCT among women with subtype A versus D.