Journal ArticleDOI
Many facets of mammalian lanosterol 14α-demethylase from the evolutionarily conserved cytochrome P450 family CYP51
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TLDR
While sterol regulatory element binding protein (SREBP)-dependent transcriptional regulation of CYP51 contributes to synthesis of cholesterol, the germ-cell-specific cAMP/CREMtau-dependent upregulation might contribute to increased production of MAS.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2003-01-01. It has received 95 citations till now. The article focuses on the topics: Sterol Regulatory Element Binding Protein 1 & Sterol 14-Demethylase.read more
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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
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Cellular cholesterol trafficking and compartmentalization
TL;DR: Increased understanding of these processes and their integration at the organ systems level provides fundamental insights into the physiology of cholesterol trafficking.
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Comparative Genomics of Rice and Arabidopsis. Analysis of 727 Cytochrome P450 Genes and Pseudogenes from a Monocot and a Dicot
TL;DR: In this paper, data mining methods have been used to identify 356 Cyt P450 genes and 99 related pseudogenes in the rice (Oryza sativa) genome using sequence information available from both the indica and japonica strains.
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Sterol 14α-Demethylase Cytochrome P450 (CYP51), a P450 in all Biological Kingdoms
TL;DR: Experimental support is presented for the notion that specific conserved regions in the P450 sequences represent a CYP51 signature, and two possible roles of CYP 51 in P450 evolution are discussed.
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Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.
Katsutaka Oishi,Koyomi Miyazaki,Koji Kadota,Reiko Kikuno,Takahiro Nagase,G Atsumi,Naoki Ohkura,Takashi Azama,Miho Mesaki,Shima Yukimasa,Hisato Kobayashi,Chisato Iitaka,Chisato Iitaka,Takashi Umehara,Masami Horikoshi,Takashi Kudo,Yoshihisa Shimizu,Masahiko Yano,Morito Monden,Kazuhiko Machida,Juzo Matsuda,Shuichi Horie,Takeshi Todo,Norio Ishida,Norio Ishida,Norio Ishida +25 more
TL;DR: The results showed that CLOCK and CRY proteins are involved in the transcriptional regulation of many circadian output genes in the mouse liver and appears to be involved in various physiological functions such as cell cycle, lipid metabolism, immune functions, and proteolysis in peripheral tissues.
References
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Regulated Intramembrane Proteolysis: A Control Mechanism Conserved from Bacteria to Humans
TL;DR: This research is supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
TL;DR: These regulated proteolytic cleavage reactions are ultimately responsible for controlling the level of cholesterol in membranes, cells, and blood.
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The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
TL;DR: This work presents a detailed description of the structure-function relationships and models of FSH-FSH Receptor interaction, and some of the mechanisms behind the interaction between the FSH and FSH receptor have been described.
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Processed Pseudogenes: Characteristics and Evolution
TL;DR: It is suggested that all the transcripts that gave rise to these pseudogenes were actually produced in the germ line cell, and that at least one processed pseudogene, the human DHFR psi 1, has been formed so recently that it is polymorphic.