Martine Mazel

TL;DR: Evidence is provided that PD‐L1 is frequently expressed on metastatic cells circulating in the blood of hormone receptor‐positive, HER2‐negative breast cancer patients and the established CTC/PD‐L 1 assay can be used for liquid biopsy in future clinical trials for stratification and monitoring of cancer patients undergoing immune checkpoint blockade.

TL;DR: Two subgroups of fish virus-induced IFNs have been defined based on conserved cysteines, and it is found that this subdivision correlates with receptor usage and all zebrafish IFNφs do not bind to the same receptor.

TL;DR: It is demonstrated that detection of CTCs overexpressing PD-L1 is feasible and may provide important prognostic information in HNSCC, and suggest that adjuvant PD1 inhibitors deserve evaluation in H NSCC patients in whom PD- L1(+) C TCs are detected at the end of curative treatment.

TL;DR: CTC-based liquid biopsies have the potential to monitor MRD in patients with non-metastatic prostate cancer by combining three independent CTC assays: the CellSearch system, an in vivo CellCollector and the EPISPOT.

TL;DR: The zebrafish genome contains a large number of genes encoding potential cytokine receptor genes as judged by homology to mammalian receptors, and morpholino-mediated loss-of-function analysis is used to screen candidate receptors and identify the components of their receptor complexes.