J
Jean-Pierre Levraud
Researcher at Pasteur Institute
Publications - 79
Citations - 4286
Jean-Pierre Levraud is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Zebrafish & Innate immune system. The author has an hindex of 35, co-authored 72 publications receiving 3525 citations. Previous affiliations of Jean-Pierre Levraud include Université Paris-Saclay & French Institute of Health and Medical Research.
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Journal ArticleDOI
The Antiviral Innate Immune Response in Fish: Evolution and Conservation of the IFN System
Christelle Langevin,Elina Aleksejeva,Gabriella Passoni,Nuno Palha,Nuno Palha,Nuno Palha,Jean-Pierre Levraud,Jean-Pierre Levraud,Pierre Boudinot +8 more
TL;DR: By comparing the IFN system between teleosts and mammals, this review will focus on its evolution in vertebrates, suggesting that it originated in early vertebrates.
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Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System
Jean-Pierre Levraud,Pierre Boudinot,Ingrid Colin,Abdenour Benmansour,Nadine Peyriéras,Philippe Herbomel,Georges Lutfalla +6 more
TL;DR: Based on the organization of the zIFN gene and the protein structure of the identified receptor components, the virus-induced fish IFNs appear as orthologs of mammalian IFN-λ, specifying type III IFN as the ancestral antiviral system of vertebrates.
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The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains.
Dina Aggad,Martine Mazel,Pierre Boudinot,Knud Erik Mogensen,Ole J. Hamming,Rune Hartmann,Sergei V. Kotenko,Philippe Herbomel,Georges Lutfalla,Jean-Pierre Levraud +9 more
TL;DR: Two subgroups of fish virus-induced IFNs have been defined based on conserved cysteines, and it is found that this subdivision correlates with receptor usage and all zebrafish IFNφs do not bind to the same receptor.
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Identification of polarized macrophage subsets in zebrafish
Mai Nguyen-Chi,Béryl Laplace-Builhé,Jana Travnickova,Patricia Luz-Crawford,Gautier Tejedor,Quang Tien Phan,Isabelle Duroux-Richard,Jean-Pierre Levraud,Karima Kissa,Georges Lutfalla,Christian Jorgensen,Farida Djouad +11 more
TL;DR: The results reveal the diversity and plasticity of zebrafishmacrophage subsets and underline the similarities with mammalian macrophages proposing a new system to study macrophage functional dynamic.
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Characterization and localization of the neonatal Fc receptor in adult human kidney.
Jean-Philippe Haymann,Jean-Pierre Levraud,Sandrine Bouet,Vincent Kappes,Jacqueline Hagège,Geneviève Nguyen,Yichun Xu,Eric Rondeau,Jean-Daniel Sraer +8 more
TL;DR: In immunofluorescence and immunohistochemical studies using normal adult human kidney sections, the presence of the so-called neonatal Fc receptor (FcRn) was demonstrated on GEC as well as in the brush border of proximal tubular cells.