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Delphine Rossille
Researcher at University of Rennes
Publications - 34
Citations - 1326
Delphine Rossille is an academic researcher from University of Rennes. The author has contributed to research in topics: Follicular lymphoma & B cell. The author has an hindex of 13, co-authored 27 publications receiving 1083 citations. Previous affiliations of Delphine Rossille include French Institute of Health and Medical Research.
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Journal ArticleDOI
Frequent expression of PD-L1 on circulating breast cancer cells.
Martine Mazel,William Jacot,Klaus Pantel,Kai Bartkowiak,Delphine Topart,Laure Cayrefourcq,Delphine Rossille,Thierry Maudelonde,Thierry Fest,Catherine Alix-Panabières +9 more
TL;DR: Evidence is provided that PD‐L1 is frequently expressed on metastatic cells circulating in the blood of hormone receptor‐positive, HER2‐negative breast cancer patients and the established CTC/PD‐L 1 assay can be used for liquid biopsy in future clinical trials for stratification and monitoring of cancer patients undergoing immune checkpoint blockade.
Journal ArticleDOI
High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial
Delphine Rossille,M. Gressier,Diane Damotte,Delphine Maucort-Boulch,Delphine Maucort-Boulch,Céline Pangault,G. Semana,S. Le Gouill,Corinne Haioun,Karin Tarte,Karin Tarte,Thierry Lamy,Noel Milpied,Thierry Fest +13 more
TL;DR: Plasma PD-L1 protein is a potent predicting biomarker in DLBCL and may indicate usefulness of alternative therapeutic strategies using PD-1 axis inhibitors and may be associated with a poorer prognosis for patients randomized within the R-CHOP arm.
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Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent T(FH)-B cell axis
Céline Pangault,Patricia Amé-Thomas,Philippe Ruminy,Delphine Rossille,Gersende Caron,Maryse Baia,J. De Vos,Mikael Roussel,Céline Monvoisin,Thierry Lamy,Hervé Tilly,P. Gaulard,Karin Tarte,Thierry Fest +13 more
TL;DR: It is demonstrated that tumor-infiltrating TFH specifically express functional IL-4 in FL, creating an IL- 4-dependent TFH–B cell axis that could sustain FL pathogenesis and represent a new potential therapeutic target.
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Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes
Fabien Guilloton,Gersende Caron,Cédric Ménard,Ceéline Pangault,Patricia Amé-Thomas,Joelle Dulong,John De Vos,Delphine Rossille,Catherine Henry,Thierry Lamy,Olivier Fouquet,Thierry Fest,Karin Tarte +12 more
TL;DR: It is shown here that BM-MSCs obtained from patients with follicular lymphoma display a specific gene expression profile compared with MSCs obtained from healthy age-matched donors (HD-MSC), highlighting the complex role of FL stromal cells that promote direct tumor B-cell growth and orchestrate FL-cell niche.
Journal ArticleDOI
T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells
Imane Azzaoui,Fabrice Uhel,Delphine Rossille,Céline Pangault,Joelle Dulong,Jerome Le Priol,Thierry Lamy,Roch Houot,Steven Le Gouill,Guillaume Cartron,Pascal Godmer,Krimo Bouabdallah,Noel Milpied,Gandhi Damaj,Karin Tarte,Thierry Fest,Mikael Roussel +16 more
TL;DR: Expanded MDSC subsets in DLBCL are identified, as well as new mechanisms of immunosuppression inDLBCL, which includes a myeloid suppressive signature and mechanisms of suppression.