Marucia Chacur

TL;DR: The present studies demonstrate that both ipsilateral and mirror-image SIN-induced allodynias are reversed by intrathecal (peri-spinal) delivery of fluorocitrate, a glial metabolic inhibitor, and provide the first evidence that ipsilaterally and Mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions.

TL;DR: It is revealed that zymosan acutely injected around the sciatic nerve of awake unrestrained rats rapidly produces low threshold mechanical allodynia in the absence of thermal hyperalgesia, and several lines of evidence are provided that the appearance of this contralateral (‘mirror’) allodynian reflects local actions of zymOSan on the sciata rather than spread of this immune activator to the general circulation.

TL;DR: These initial investigations of spinal fractalkine effects suggest that exogenous and endogenous fractalkines are involved in spinal sensitization, including that induced by peripheral neuropathy.

TL;DR: This work reviews the proinflammatory and nociceptive effects evoked by myotoxic PLA2s and their mechanisms of action and concludes that these proteins promote inflammation and pain by mechanisms not related to phospholipid hydrolysis nor to mobilization of arachidonic acid.

TL;DR: Initial support is provided that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain.