M
Mary Adams
Researcher at King's College London
Publications - 39
Citations - 1479
Mary Adams is an academic researcher from King's College London. The author has contributed to research in topics: Lenalidomide & Antibody-dependent cell-mediated cytotoxicity. The author has an hindex of 14, co-authored 36 publications receiving 1280 citations. Previous affiliations of Mary Adams include University of Kent & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20+ Tumor Cells
Lei Wu,Mary Adams,Troy Carter,Roger Shen-Chu Chen,George W. Muller,David I. Stirling,Peter H. Schafer,J. Blake Bartlett +7 more
TL;DR: It is suggested that lenalidomide has the potential to enhance the rituximab-induced killing of NHL cell lines and primary B-cell chronic lymphocytic leukemia cells via a NK cell-mediated and monocyte-mediated ADCC mechanism in vitro, providing a strong rationale for the combination of lenalidumide with IgG1 antibodies to target tumor-specific antigens in patients with cancer.
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Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Peter H. Schafer,Anastasia Parton,Anita Gandhi,Lori Capone,Mary Adams,Lei Wu,Justin B. Bartlett,Loveland Ma,Amos Gilhar,Cheung Yf,George S. Baillie,Houslay,Man Hw,G. W. Muller,D. I. Stirling +14 more
TL;DR: The inhibitory effects of apremilast on pro‐inflammatory responses of human primary peripheral blood mononuclear cells, polymorphonuclear Cells, natural killer cells and epidermal keratinocytes were explored in vitro, and in a preclinical model of psoriasis.
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'Poppets and parcels': the links between staff experience of work and acutely ill older peoples' experience of hospital care
TL;DR: The work experiences of staff in a MfOP service impacted directly on patient care experience, leading staff to seek job satisfaction through caring for 'poppets', leaving less favoured patients to receive less personalised care.
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Barriers and opportunities for enhancing patient recruitment and retention in clinical research: findings from an interview study in an NHS academic health science centre.
TL;DR: Current systematic challenges to patient recruitment and retention in clinical studies more generally as seen from the perspective of staff at the 'sharp end’ of recruiting are highlighted.
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Lenalidomide enhances antibody-dependent cellular cytotoxicity of solid tumor cells in vitro: influence of host immune and tumor markers
TL;DR: Lenalidomide enhances the ability of IgG1-isotype antibodies to mediate ADCC of solid tumor cells, the extent of which is largely dependent on NKG2D–NKG2d ligand interactions, but appears to be independent of MIC-A/B.