Mary E.P. Goad

TL;DR: A potent myostatin inhibitor, a soluble form of the activin type IIB receptor (ACVR2B), is described, which can cause dramatic increases in muscle mass when injected into wild-type mice.

TL;DR: IL-13 receptor (R)α2 is a critical down-regulatory factor of IL-13–mediated tissue fibrosis induced by the parasitic helminth Schistosoma mansoni, illustrating the central role played by the IL- 13Rα2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response.

TL;DR: It is shown that mice with a compound deficiency in Jnk expression can survive to birth, but fail to close the optic fissure (retinal coloboma), and the role of JNK to regulate BMP4 expression during optic fISSure closure is conserved in Drosophila during dorsal closure.

TL;DR: It is concluded that JNK is necessary for epithelial morphogenesis and is an essential regulator of signal transduction by the EGF receptor in the epidermis.

TL;DR: Efficacy was dependent on immune activity and was not associated with toxicity, suggesting potential for recombinant human B7.2-Ig as an adjuvant to chemotherapy in promoting immune-mediated mechanisms to augment the activity of chemotherapy.