K
Kathy Tomkinson
Researcher at Pfizer
Publications - 9
Citations - 1662
Kathy Tomkinson is an academic researcher from Pfizer. The author has contributed to research in topics: Myostatin & Interleukin 1 receptor, type I. The author has an hindex of 4, co-authored 9 publications receiving 1585 citations. Previous affiliations of Kathy Tomkinson include Johns Hopkins University & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Induction of cachexia in mice by systemically administered myostatin
Teresa A. Zimmers,Monique V. Davies,Leonidas G. Koniaris,Paul A. Haynes,Aurora F. Esquela,Kathy Tomkinson,Alexandra C. McPherron,Neil M. Wolfman,Se-Jin Lee +8 more
TL;DR: It is shown that myostatin circulates in the blood of adult mice in a latent form that can be activated by acid treatment, and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired.
Journal ArticleDOI
Regulation of muscle growth by multiple ligands signaling through activin type II receptors
Se-Jin Lee,Lori A. Reed,Monique V. Davies,Stefan Girgenrath,Mary E.P. Goad,Kathy Tomkinson,Jill F. Wright,Christopher M. Barker,Gregory Ehrmantraut,James Holmstrom,Betty Trowell,Barry Gertz,Man Shiow Jiang,Suzanne Sebald,Martin M. Matzuk,En Li,En Li,Li Fang Liang,Edwin Quattlebaum,Ronald L. Stotish,Neil M. Wolfman +20 more
TL;DR: A potent myostatin inhibitor, a soluble form of the activin type IIB receptor (ACVR2B), is described, which can cause dramatic increases in muscle mass when injected into wild-type mice.
Journal ArticleDOI
Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.
Jing Li,Kathy Tomkinson,Xiang-Yang Tan,Paul W. Wu,Grace Yan,Vikki Spaulding,Bijia Deng,Bethany Annis-Freeman,Kathleen Heveron,Richard Zollner,Gerard De Zutter,Jill F. Wright,Tara K. Crawford,Wei Liu,Kenneth Jacobs,Neil M. Wolfman,Vincent Ling,Debra D. Pittman,Geertruida M. Veldman,Lynette A. Fouser +19 more
TL;DR: A temporal model for the development of a functional IL-22 cytokine-receptor-Fc complex is proposed, based on data studied, which indicates that the IL-10R2(ECD) binds to a surface created by the interaction between IL- 22 and the Il-22R(ECD), and thereby further stabilizes the association ofIL-22 within this cytokine/receptor complex.
Patent
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
Se-Jin Lee,Alexandra C. McPherron,Daniel S. Greenspan,William N. Pappano,Neil M. Wolfman,Kathy Tomkinson +5 more
TL;DR: In this paper, it was determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostin to an active form.
Patent
Activacion de miostatina por metaloproteasa, y metodos para modular la actividad de miostatina.
Se-Jin Lee,Alexandra C. McPherron,Daniel S Greenspan,William N. Pappano,Neil Wolfman,Kathy Tomkinson +5 more
TL;DR: In vitro, un metodo in vitro for disminuir the activación of miostatina was proposed, in which a metaloproteinasa was used to escindir the propeptido de miostata.