A
Arne Wrede
Researcher at Saarland University
Publications - 46
Citations - 1934
Arne Wrede is an academic researcher from Saarland University. The author has contributed to research in topics: Scrapie & Camptocormia. The author has an hindex of 22, co-authored 42 publications receiving 1703 citations. Previous affiliations of Arne Wrede include University of Göttingen.
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Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
Marcel Grapp,Arne Wrede,Michaela Schweizer,Sabine Hüwel,Hans-Joachim Galla,Nicolas Snaidero,Mikael Simons,Johanna Bückers,Philip S. Low,Henning Urlaub,Jutta Gärtner,Robert Steinfeld +11 more
TL;DR: The results unravel a new pathway of folate receptor-α-dependent exosome-mediated folate delivery into the brain parenchyma and opens new avenues for cerebral drug targeting.
Journal ArticleDOI
Screening of innate immune receptors in neurodegenerative diseases: a similar pattern.
Maryse Letiembre,Yang Liu,Silke Walter,Wenlin Hao,Tatjana Pfander,Arne Wrede,Walter J. Schulz-Schaeffer,Klaus Fassbender +7 more
TL;DR: A uniform pattern of innate immune response in animal models of neurodegenerative diseases clearly indicates that this response is part of a non-specific neuroinflammatory effector phase rather than a disease-specific event.
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Deletion of Cellular Prion Protein Results in Reduced Akt Activation, Enhanced Postischemic Caspase-3 Activation, and Exacerbation of Ischemic Brain Injury
Jens Weise,Raoul Sandau,Sönke Schwarting,Olaf Crome,Arne Wrede,Walter J. Schulz-Schaeffer,Inga Zerr,Mathias Bähr +7 more
TL;DR: It is demonstrated that PrPc deletion impairs the antiapoptotic phosphatidylinositol 3-kinase/Akt pathway by resulting in reduced postischemic phospho-Akt expression, followed by enhanced caspase-3 activation, and aggravated neuronal injury after transient and permanent cerebral ischemia.
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β-amyloid is a substrate of autophagy in sporadic inclusion body myositis
Jan D. Lünemann,Jens Schmidt,Dorothee Schmid,K. Barthel,Arne Wrede,Marinos C. Dalakas,Christian Münz +6 more
TL;DR: In this article, the authors demonstrate that Atg8/LC3 colocalizes with APP in cultured human muscle cells and demonstrate that the autophagy pathway should be explored for its potential therapeutic merit in sIBM.
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Camptocormia in idiopathic Parkinson's disease: A focal myopathy of the paravertebral muscles
Nils G. Margraf,Arne Wrede,Axel Rohr,Walter J. Schulz-Schaeffer,Jan Raethjen,Andrea Eymess,Jens Volkmann,Maximilian Mehdorn,Olav Jansen,Günther Deuschl +9 more
TL;DR: The findings suggest that the myopathy has a progressive course, which finally leads to degeneration of the paravertebral muscles, a major disabling, non‐fluctuating and levodopa‐resistant complication of advanced PD.