M
Masafumi Umekage
Researcher at Kyoto University
Publications - 5
Citations - 1276
Masafumi Umekage is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Regenerative medicine. The author has an hindex of 3, co-authored 3 publications receiving 886 citations.
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Journal ArticleDOI
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more
TL;DR: At 1 year after surgery, the transplanted sheet of retinal pigment epithelial cells remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present.
Journal ArticleDOI
Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease
Daisuke Doi,Hiroaki Magotani,Tetsuhiro Kikuchi,Megumi Ikeda,Hiramatsu Satoe,Yoshida Kenji,Naoki Amano,Masaki Nomura,Masafumi Umekage,Asuka Morizane,Jun Takahashi +10 more
TL;DR: A comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line finds that when the DAPs are transplanted into the striatum of 6-OHDA-lesioned rats, the animals show behavioral improvement.
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Overview: an iPS cell stock at CiRA.
TL;DR: The iPSC stock is recruited from healthy, consenting HLA-type homozygous donors and is made with peripheral blood-derived mononuclear cells or umbilical cord blood and is intended to be offered not only to Japanese centers but also overseas medical institutions and companies.
Journal ArticleDOI
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.
Shinsuke Yoshida,Tomoaki M. Kato,Yoshiko Sato,Masafumi Umekage,Tomoko Ichisaka,Masayoshi Tsukahara,Naoko Takasu,Shinya Yamanaka +7 more
TL;DR: A clinical-grade haplobank of 27 human induced pluripotent stem cells (iPSC) lines from seven HLA-homozygous donors was established in this article .
Journal ArticleDOI
Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application
Yuko Kitano,Sayaka Nishimura,Tomoaki M. Kato,Anna Ueda,Kaho Takigawa,Masafumi Umekage,Masaki Nomura,Ayane Kawakami,Haruna Ogawa,Huaigeng Xu,Akitsu Hotta,Naoko Takasu,Masayoshi Tsukahara +12 more
TL;DR: In this paper , the authors optimized the protocol for good manufacturing practice (GMP)-compatible CRISPR-Cas9 genome editing to deplete the three gene locus (HLA-A, HLA-B, and CIITA genes) simultaneously in HLA homozygous iPSCs.