Y
Yasuhiko Hirami
Researcher at Kyoto University
Publications - 65
Citations - 3653
Yasuhiko Hirami is an academic researcher from Kyoto University. The author has contributed to research in topics: Retinitis pigmentosa & Transplantation. The author has an hindex of 23, co-authored 57 publications receiving 2986 citations.
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Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more
TL;DR: At 1 year after surgery, the transplanted sheet of retinal pigment epithelial cells remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present.
Journal ArticleDOI
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
Fumitaka Osakada,Zi-Bing Jin,Yasuhiko Hirami,Hanako Ikeda,Teruko Danjyo,Kiichi Watanabe,Yoshiki Sasai,Masayo Takahashi +7 more
TL;DR: In this paper, a defined culture method using low-molecular mass compounds that induce differentiation of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells into retinal progenitors, retinal pigment epithelium cells and photoreceptors was devised.
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Generation of retinal cells from mouse and human induced pluripotent stem cells.
Yasuhiko Hirami,Fumitaka Osakada,Kazutoshi Takahashi,Keisuke Okita,Shinya Yamanaka,Hanako Ikeda,Nagahisa Yoshimura,Masayo Takahashi +7 more
TL;DR: It is proposed that iPSCs can be induced to differentiate into retinal cells which have a possibility to be used as patient-specific donor cells for transplantation therapies.
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Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells
Zi-Bing Jin,Satoshi Okamoto,Fumitaka Osakada,Kohei Homma,Juthaporn Assawachananont,Yasuhiko Hirami,Takeshi Iwata,Masayo Takahashi +7 more
TL;DR: The use of patient-derived iPS cells will help to elucidate the pathogenic mechanisms caused by genetic mutations in RP, and recapitulated the disease phenotype and expressed markers of cellular stresses.
Journal ArticleDOI
Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy.
Yasuhiko Hirami,Akitaka Tsujikawa,Atsushi Otani,Yuko Yodoi,Hiroko Aikawa,Michiko Mandai,Nagahisa Yoshimura +6 more
TL;DR: Subretinal hemorrhage after PDT can be a common complication in patients with PCV and may have a minor effect on visual outcome, however, postoperative hemorrhage is occasionally so massive that it leads to vitreous hemorrhage and poor visual prognosis.