Shin Kawamata

TL;DR: At 1 year after surgery, the transplanted sheet of retinal pigment epithelial cells remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present.

TL;DR: It is shown that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs and suggested that generation of transgene-free iPSCS from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future.

TL;DR: The tumorigenic potential of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of wet-type, age-related macular degeneration (AMD) is reported and it is concluded that the iPSC-derived RPE was negligible.

TL;DR: Three in vitro assay methods to detect undifferentiated hiPSCs are examined, providing highly sensitive and quantitative in vitro assays essential for facilitating safety profiling of hiPSC-derived products for future regenerative medicine research.

TL;DR: Initial recommendations on the minimum dataset required to consider an iPSC line of clinical grade are outlined in this report, which are likely to lead to revision of these guidelines on a regular basis.