M
Masahiro J. Go
Researcher at Foundation for Biomedical Research
Publications - 7
Citations - 1309
Masahiro J. Go is an academic researcher from Foundation for Biomedical Research. The author has contributed to research in topics: Transplantation & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 6 publications receiving 1009 citations.
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Journal ArticleDOI
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more
TL;DR: At 1 year after surgery, the transplanted sheet of retinal pigment epithelial cells remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present.
Journal ArticleDOI
Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration.
Hoshimi Kanemura,Masahiro J. Go,Masayuki Shikamura,Naoki Nishishita,Noriko Sakai,Hiroyuki Kamao,Michiko Mandai,Chikako Morinaga,Masayo Takahashi,Shin Kawamata +9 more
TL;DR: The tumorigenic potential of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of wet-type, age-related macular degeneration (AMD) is reported and it is concluded that the iPSC-derived RPE was negligible.
Journal ArticleDOI
Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products
TL;DR: The points to be considered in the design and execution of tumorigenicity tests are outlined, referring to the tests and laboratory work that have been conducted for an iPSC-derived retinal pigment epithelium (RPE) cell product prior to its clinical use.
Journal ArticleDOI
Pigment epithelium-derived factor secreted from retinal pigment epithelium facilitates apoptotic cell death of iPSC.
Hoshimi Kanemura,Masahiro J. Go,Naoki Nishishita,Noriko Sakai,Hiroyuki Kamao,Yoji Sato,Masayo Takahashi,Shin Kawamata +7 more
TL;DR: It is shown that pigment epithelium-derived factor (PEDF), which is secreted from primary or iPSC-derived retinal pigment epithellium (RPE), dramatically inhibits the growth of iPSCs, and tumor formation in NOG mice after subcutaneous injection with or without an iPSc-derived RPE sheet is examined.
Patent
Cell sorting method
TL;DR: A pigment epithelium-derived factor with the differentiated cell population to induce apoptosis of the undifferentiated cells was used for cell transplantation therapy and for inducing apoptosis as discussed by the authors.