M
Masahiko Watanabe
Researcher at University of Tsukuba
Publications - 69
Citations - 4194
Masahiko Watanabe is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Nitroreductase & Acetyltransferase. The author has an hindex of 31, co-authored 69 publications receiving 4019 citations. Previous affiliations of Masahiko Watanabe include University of Tokyo & National Cancer Research Institute.
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Journal ArticleDOI
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Yuko Nakabayashi,Yuko Nakabayashi,Ikuko Mizuta,Ikuko Mizuta,Yushi Hirota,Yushi Hirota,Chiyomi Ito,Chiyomi Ito,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Masahiko Watanabe,Atsushi Takeda,Hiroyuki Tomiyama,Kenji Nakashima,Kazuko Hasegawa,Fumiya Obata,Takeo Yoshikawa,Hideshi Kawakami,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda,Tatsushi Toda +26 more
TL;DR: The results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.
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Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels
TL;DR: The results indicate that the new strains permit the efficient detection of the mutagenicity of environmental nitroarenes and aromatic amines.
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Mutagenicity of 30 chemicals in Salmonella typhimurium strains possessing different nitroreductase or O-acetyltransferase activities.
TL;DR: In this article, Salmonella typhimurium YG1021, YG1024, XG1026 and YG 1029 are new derivatives of the Ames tester strains TA98 and TA100, with elevated N-hydroxyarylamine O-acetyltransferase level.
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Abundant Expression and Cytoplasmic Aggregations of α1A Voltage-Dependent Calcium Channel Protein Associated with Neurodegeneration in Spinocerebellar Ataxia Type 6
K. Ishikawa,K. Ishikawa,Hiroto Fujigasaki,Hironao Saegusa,Kiyoshi Ohwada,Tsuneo Fujita,Hiroyuki Iwamoto,Yasuko Komatsuzaki,Shuta Toru,Hideyuki Toriyama,Masahiko Watanabe,Norio Ohkoshi,Shin'ichi Shoji,Ichiro Kanazawa,Tsutomu Tanabe,HidehiroMizusawa +15 more
TL;DR: The present study indicates that the mechanism of neurodegeneration in SCA6 is associated with cytoplasmic aggregations of the [alpha]1A calcium channel protein caused by a small CAG repeat/polyglutamine expansion in CACNA1A.
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A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100.
TL;DR: 'Classical nitroreductase' is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes and the introduced strains had more than 50 times higher nitrofurazone-reductase activity than TA1538 containing pBR322.