Masahiro Kondo

TL;DR: Evidence is presented that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin-superfamily receptor Down syndrome cell adhesion molecule (Dscam), and the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.

TL;DR: Overexpression of the same Dscam isoforms in two da neurons with overlapping dendritic fields forced a spatial segregation of the two fields, supporting the model that d endritic branches of da neurons use isoform-specific homophilic interactions to ensure minimal overlap.

TL;DR: The role of Dscam in neuron-target recognition of single mechanosensory neurons, which connect with different target cells through multiple axonal branches, is examined and a very large number of structurally unique receptor isoforms is required to ensure fidelity and precision of neuronal connectivity.

TL;DR: Findings provide the first documentation that astroglia is involved in the enhanced nociceptive responses of functionally identified Vc nocICEptive neurons and in the associated orofacial hyperalgesia following trigeminal nerve injury.

TL;DR: Tofacitinib, a JAK1/JAK3 inhibitor, affected the activities of human DCs and decreased CD80/CD86 expression and T cell stimulatory capability through suppression of type I IFN signalling, suggesting a novel mode of action and a pivotal role for JAKs in the differentiation of DCs.