F
Franziska Thomas
Researcher at Harvard University
Publications - 5
Citations - 971
Franziska Thomas is an academic researcher from Harvard University. The author has contributed to research in topics: Phosphorylation & Innate immune system. The author has an hindex of 3, co-authored 3 publications receiving 916 citations.
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Journal ArticleDOI
Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
Fiona L. Watson,Roland Püttmann-Holgado,Franziska Thomas,David L. Lamar,Michael Hughes,Masahiro Kondo,Vivienne I. Rebel,Dietmar Schmucker +7 more
TL;DR: Evidence is presented that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin-superfamily receptor Down syndrome cell adhesion molecule (Dscam), and the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.
Journal ArticleDOI
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation
TL;DR: It is shown that a transmembrane receptor, DCC, forms a binding complex containing multiple translation components, including eukaryotic initiation factors, ribosomal large and small subunits, and monosomes, in neuronal axons and dendrites.
Journal ArticleDOI
Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1.
Dan Dascenco,Maria-Luise Erfurth,Azadeh Izadifar,Minmin Song,Sonja Sachse,Rachel Bortnick,Olivier Urwyler,Milan Petrovic,Derya Ayaz,Haihuai He,Yoshiaki Kise,Franziska Thomas,Thomas Kidd,Dietmar Schmucker +13 more
TL;DR: It is reported that cell-autonomous loss of the receptor tyrosine phosphatase 69D (RPTP69D) and loss of midline-localized Slit inhibit formation of specific axon collaterals through modulation of Dscam1 activity, enabling the spatial specificity of axon collateral formation.
Proceedings ArticleDOI
Design of a Thermostable WW Domain Scaffold
Journal ArticleDOI
Identification of novel functional mini-receptors by combinatorial screening of split-WW domains
Hermann Neitz,Niels B Paul,Florian R Häge,Christina Lindner,Roman Graebner,Michael Kovermann,Franziska Thomas +6 more
TL;DR: A combinatorial approach to identify novel functional mini-proteins based on the WW-domain scaffold is presented, which takes advantage of the successful reconstitution of the fragmented WW domain of hPin1 (hPin1WW) by CC association.