M
Masamichi Aikawa
Researcher at Tokai University
Publications - 285
Citations - 15291
Masamichi Aikawa is an academic researcher from Tokai University. The author has contributed to research in topics: Plasmodium falciparum & Immunoelectron microscopy. The author has an hindex of 69, co-authored 285 publications receiving 14950 citations. Previous affiliations of Masamichi Aikawa include National Institutes of Health & Walter Reed Army Institute of Research.
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Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite
TL;DR: Invasion of erythrocytes by merozoites of the monkey malaria, Plasmodium knowlesi, was investigated by electron microscopy and the movement of the junction during invasion is an important component of the mechanism by which themerozoite enters the ery Throcyte.
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Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite
TL;DR: Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells with monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoite.
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Human cerebral malaria.
TL;DR: From electron microscopic results, it was concluded that knobs on infected erythrocytes acted as focal junctions which mediated adhesion to endothelial cells and are important contributors to the blockage of the capillary lumen and ensuing pathological changes in cerebral tissues.
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A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
TL;DR: The Mr 28,000 cysteine proteinase has a critical, perhaps rate-limiting, role in hemoglobin degradation within the food vacuole of Plasmodium falciparum and specific inhibitors of this enzyme might provide new means of antimalarial chemotherapy.
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Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytes
Russell J. Howard,Shigehiko Uni,Masamichi Aikawa,Stephen B. Aley,J H Leech,Andrew M. Lew,Thomas E. Wellems,J Rener,D W Taylor +8 more
TL;DR: Results provide evidence for an intracellular route of transport for a secreted malarial protein from the parasite through several membranes and the host cell cytoplasm.