M
Masashi Izumiya
Researcher at University of Tokyo
Publications - 28
Citations - 2092
Masashi Izumiya is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Carcinogenesis. The author has an hindex of 12, co-authored 19 publications receiving 1863 citations. Previous affiliations of Masashi Izumiya include National Cancer Research Institute.
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Journal ArticleDOI
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
TL;DR: Evidence is provided that miR-34a functions as a potent suppressor of cell proliferation through modulation of the E2F signaling pathway, which could contribute to aberrant cell proliferation, leading to colon cancer development.
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Circulating Exosomal microRNAs as Biomarkers of Colon Cancer
Hiroko Ogata-Kawata,Masashi Izumiya,Daisuke Kurioka,Yoshitaka Honma,Yasuhide Yamada,Koh Furuta,Toshiaki Gunji,Hideki Ohta,Hiroyuki Okamoto,Hikaru Sonoda,Masatoshi Watanabe,Hitoshi Nakagama,Jun Yokota,Takashi Kohno,Naoto Tsuchiya +14 more
TL;DR: Exosomal miRNA signatures appear to mirror pathological changes of CRC patients and several miRNAs are promising biomarkers for non-invasive diagnosis of the disease.
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Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21
Naoto Tsuchiya,Masashi Izumiya,Hiroko Ogata-Kawata,Koji Okamoto,Yuko Fujiwara,Makiko Nakai,Atsushi Okabe,Aaron J. Schetter,Elise D. Bowman,Yutaka Midorikawa,Yasuyuki Sugiyama,Hiroyuki Aburatani,Curtis C. Harris,Hitoshi Nakagama +13 more
TL;DR: The identification of the microRNA miR-22 as a p53 target gene that selectively determines the induction of p53-dependent apoptosis by repressing p21 is reported, defining an intrinsic molecular switch that determines p 53-dependent cellular fate through post-transcriptional regulation of p21.
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Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer
Shinya Akatsuka,Yoriko Yamashita,Hiroki Ohara,Yu-Ting Liu,Masashi Izumiya,Koichiro Abe,Masako Ochiai,Li Jiang,Hirotaka Nagai,Hirotaka Nagai,Yasumasa Okazaki,Hideki Murakami,Yoshitaka Sekido,Eri Arai,Yae Kanai,Okio Hino,Takashi Takahashi,Hitoshi Nakagama,Shinya Toyokuni +18 more
TL;DR: It is suggested that an iron-dependent Fenton chemical reaction causes large-scale genomic alterations during carcinogenesis, which may result in distinct genomic profiles in humans.
Journal ArticleDOI
miR‐493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver
Koji Okamoto,Tatsuya Ishiguro,Yutaka Midorikawa,Hirokazu Ohata,Masashi Izumiya,Naoto Tsuchiya,Ai Sato,Hiroaki Sakai,Hitoshi Nakagama +8 more
TL;DR: It is proposed that, in a subset of colon cancer, upregulation of miR‐493 during carcinogenesis prevents liver metastasis via the induction of cell death of metastasized cells.