J
Jun Yokota
Researcher at National Cancer Research Institute
Publications - 292
Citations - 24829
Jun Yokota is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Gene & Lung cancer. The author has an hindex of 82, co-authored 292 publications receiving 23577 citations. Previous affiliations of Jun Yokota include Epigenomics AG & Jikei University School of Medicine.
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Journal ArticleDOI
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara,Natasha J. Caplen,Elise D. Bowman,Masahiro Seike,Kensuke Kumamoto,Ming Yi,Robert M. Stephens,Aikou Okamoto,Jun Yokota,Tadao Tanaka,George A. Calin,Chang Gong Liu,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
Journal ArticleDOI
Circulating Exosomal microRNAs as Biomarkers of Colon Cancer
Hiroko Ogata-Kawata,Masashi Izumiya,Daisuke Kurioka,Yoshitaka Honma,Yasuhide Yamada,Koh Furuta,Toshiaki Gunji,Hideki Ohta,Hiroyuki Okamoto,Hikaru Sonoda,Masatoshi Watanabe,Hitoshi Nakagama,Jun Yokota,Takashi Kohno,Naoto Tsuchiya +14 more
TL;DR: Exosomal miRNA signatures appear to mirror pathological changes of CRC patients and several miRNAs are promising biomarkers for non-invasive diagnosis of the disease.
Journal ArticleDOI
Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
Tsutomu Ohta,Kumiko Iijima,Mamiko Miyamoto,Izumi Nakahara,Hiroshi Tanaka,Makiko Ohtsuji,Takafumi Suzuki,Akira Kobayashi,Jun Yokota,Tokuki Sakiyama,Tatsuhiro Shibata,Masayuki Yamamoto,Setsuo Hirohashi +12 more
TL;DR: In lung cancer cells, low Keap1 activity led to nuclear localization and constitutive activation of Nrf2, which resulted in constitutive expression of cytoprotective genes encoding multidrug resistance pumps, phase II detoxifying enzymes, and antioxidative stress enzymes/proteins.
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Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung
TL;DR: Results indicate that recessive genetic changes involving sequences on chromosomes 3p, 13q, and 17p may play important roles in the genesis of small-cell carcinoma, and those on chromosome 3P may play an important role in the Genesis of adenocarcinoma.
Journal ArticleDOI
Familial gastric cancer: overview and guidelines for management*
Carlos Caldas,Fátima Carneiro,Henry T. Lynch,Jun Yokota,Georgia L. Wiesner,Steven M. Powell,Frank R. Lewis,David G. Huntsman,Paul D.P. Pharoah,Janusz Jankowski,Patrick MacLeod,Holger Vogelsang,Gisela Keller,Ken G M Park,Frances M. Richards,Eamonn R. Maher,Simon A. Gayther,Carla Oliveira,Nicola Grehan,Derek Wight,Raquel Seruca,Franco Roviello,Bruce A.J. Ponder,Charles E. Jackson +23 more
TL;DR: A group of geneticists, gastroenterologists, surgeons, oncologists, pathologists, and molecular biologists gathered to produce consensus statements and guidelines for familial gastric cancer confirmed that the gastric cancers were all of the diffuse type.