Masashi Kuroda

TL;DR: Accumulating evidence suggests that adipocyte death is involved in immune cell function and initiates inflammation through an interaction with macrophages; however, the precise mechanisms remain largely unknown.

TL;DR: In this article , cold exposure of tumour-bearing mice to cold conditions markedly inhibits the growth of various types of solid tumours, including clinically untreatable cancers such as pancreatic cancers.

TL;DR: In this paper , cold exposure of tumour-bearing mice to cold conditions markedly inhibits the growth of various types of solid tumours, including clinically untreatable cancers such as pancreatic cancers.

TL;DR: Analysis of BAT after 4-h exposure to cold temperature revealed that cold exposure induces UCP1-mediated thermogenesis-dependent glucose utilization and UCP2-independent active lipid metabolism in BAT, and cold exposure largely affects amino acid metabolism inBAT.

TL;DR: It is shown that adipocyte-specific PDK1 (3′-phosphoinositide–dependent kinase 1)-deficient (A-PDK1KO) mice manifest impaired metabolic actions of insulin in adipose tissue and reduction of adipOSE tissue mass and that insulin signaling in adipocytes negatively regulates the production of LTB4 via the PDK 1−FoxO1 pathway and thereby maintains systemic insulin sensitivity.