M
Masakazu Shinohara
Researcher at Kobe University
Publications - 143
Citations - 4578
Masakazu Shinohara is an academic researcher from Kobe University. The author has contributed to research in topics: SMA* & SMN1. The author has an hindex of 34, co-authored 127 publications receiving 3612 citations. Previous affiliations of Masakazu Shinohara include Japan Agency for Medical Research and Development & Brigham and Women's Hospital.
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Journal ArticleDOI
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue
TL;DR: An approach for identification of SPM pathways in human blood and lymphoid tissues that were in amounts commensurate with their pro-resolving, organ protective, and tissue regeneration functions is demonstrated.
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Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
Ikuo Kimura,Ikuo Kimura,Junki Miyamoto,Junki Miyamoto,Ryuji Ohue-Kitano,Ryuji Ohue-Kitano,Keita Watanabe,Takahiro G. Yamada,Masayoshi Onuki,Ryo Aoki,Ryo Aoki,Yosuke Isobe,Daiji Kashihara,Daisuke Inoue,Akihiko Inaba,Yuta Takamura,Satsuki Taira,Shunsuke Kumaki,Masaki Watanabe,Masato Ito,Fumiyuki Nakagawa,Junichiro Irie,Junichiro Irie,Hiroki Kakuta,Masakazu Shinohara,Ken Iwatsuki,Gozoh Tsujimoto,Hiroaki Ohno,Hiroaki Ohno,Makoto Arita,Makoto Arita,Hiroshi Itoh,Hiroshi Itoh,Koji Hase,Koji Hase +34 more
TL;DR: The authors found that maternal microbiota during pregnancy imparts resistance to obesity to their offspring, and raise the possibility that maternal SCFAs play a key role in the regulation of disease susceptibility during postnatal life in the context of the DOHaD theory.
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Oral Administration of an Active Form of Vitamin D3 (Calcitriol) Decreases Atherosclerosis in Mice by Inducing Regulatory T Cells and Immature Dendritic Cells With Tolerogenic Functions
Masafumi Takeda,Tomoya Yamashita,Naoto Sasaki,Kenji Nakajima,Tomoyuki Kita,Masakazu Shinohara,Tatsuro Ishida,Ken-ichi Hirata +7 more
TL;DR: Oral calcitriol treatment could prevent the development of atherosclerosis by changing the function or differentiation of DCs and regulatory T cells, and these findings suggest that intestinal and systemic immune modulation by calcriol may be a potentially valuable therapeutic approach against Atherosclerosis.
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Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids
Jung Ha Park,Takenori Kotani,Tasuku Konno,Jajar Setiawan,Yasuaki Kitamura,Shinya Imada,Yutaro Usui,Naoya Hatano,Masakazu Shinohara,Yasuyuki Saito,Yoji Murata,Takashi Matozaki +11 more
TL;DR: The results suggest that Gram-positive commensal bacteria are a major determinant of IEC turnover, and that their stimulatory effect is mediated by SCFAs.
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A metabolomic approach to lung cancer
Suya Hori,Shin Nishiumi,Kazuyuki Kobayashi,Masakazu Shinohara,Yukihisa Hatakeyama,Yoshikazu Kotani,Naoya Hatano,Yoshimasa Maniwa,Wataru Nishio,Takeshi Bamba,Eiichiro Fukusaki,Takeshi Azuma,Tadaomi Takenawa,Yoshihiro Nishimura,Masaru Yoshida +14 more
TL;DR: It is demonstrated that changes in metabolite pattern are useful for assessing the clinical characteristics of lung cancer and will hopefully lead to the establishment of novel diagnostic tools.