M
Masato Umeda
Researcher at Kyoto University
Publications - 40
Citations - 3257
Masato Umeda is an academic researcher from Kyoto University. The author has contributed to research in topics: Phosphatidylethanolamine & Cell membrane. The author has an hindex of 24, co-authored 40 publications receiving 2824 citations. Previous affiliations of Masato Umeda include Institute of Medical Science & Duke University.
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Journal ArticleDOI
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.
Zhaoyu Li,Luis B. Agellon,Theresa M. Allen,Masato Umeda,L D Jewell,Andrew Mason,Dennis E. Vance +6 more
TL;DR: Manipulation of PC/PE levels suggests that this ratio is a key regulator of cell membrane integrity and plays a role in the progression of steatosis into steatohepatitis and has clinical implications as patients with nonalcoholic steato hepatitis have a decreased ratio of PC to PE compared to control livers.
Journal ArticleDOI
Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
Estela Area-Gomez,Maria del Carmen Lara Castillo,Marc D Tambini,Cristina Guardia-Laguarta,Ad J. C. de Groof,Ad J. C. de Groof,Moneek Madra,Junichi Ikenouchi,Masato Umeda,Thomas D. Bird,Stephen L. Sturley,Eric A. Schon +11 more
TL;DR: It is proposed that upregulated MAM function at the ER–mitochondrial interface, and increased cross‐talk between these two organelles, may play a hitherto unrecognized role in the pathogenesis of AD.
Journal ArticleDOI
An Essential Role for a Membrane Lipid in Cytokinesis: Regulation of Contractile Ring Disassembly by Redistribution of Phosphatidylethanolamine
Kazuo Emoto,Masato Umeda +1 more
TL;DR: These findings provide the first evidence that PE is required for completion of cytokinesis in mammalian cells, and suggest that redistribution of PE on the cleavage furrow may contribute to regulation of contractile ring disassembly.
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Failure of the Expression of Phospholipid Hydroperoxide Glutathione Peroxidase in the Spermatozoa of Human Infertile Males
Hirotaka Imai,Kunio Suzuki,Kazuhiro Ishizaka,Shizuko Ichinose,Hiroyuki Oshima,Isao Okayasu,Kazuo Emoto,Masato Umeda,Yasuhito Nakagawa +8 more
TL;DR: The results suggest that failure of the expression of mitochondrial PHGPx in spermatozoa might be one of the causes of oligoasthenozoospermia in infertile men.
Journal ArticleDOI
In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy.
TL;DR: In vitro Atg8p-PE reconstitution system established will provide a powerful system for further understanding the precise role of lipidation and interaction of two ubiquitin-like systems essential for autophagy.