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Stephen L. Sturley
Researcher at Columbia University Medical Center
Publications - 92
Citations - 7889
Stephen L. Sturley is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Saccharomyces cerevisiae & Sterol O-acyltransferase. The author has an hindex of 42, co-authored 90 publications receiving 7400 citations. Previous affiliations of Stephen L. Sturley include University of Wisconsin-Madison & New York University.
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Journal ArticleDOI
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
Eugene D. Carstea,Jill A. Morris,Katherine G. Coleman,Stacie K. Loftus,Dana Zhang,Christiano Cummings,Jessie Z. Gu,Melissa A. Rosenfeld,William J. Pavan,David B. Krizman,James W. Nagle,M H Polymeropoulos,Stephen L. Sturley,Yiannis A. Ioannou,Maureen E. Higgins,Marcella E. Comly,Adele Cooney,Anthony Brown,Christine R. Kaneski,E. Joan Blanchette-Mackie,Nancy K. Dwyer,Edward B. Neufeld,Ta-Yuan Chang,Laura Liscum,Jerome F. Strauss,Kousaku Ohno,Marsha Zeigler,Rivka Carmi,J Sokol,David Markie,Raymond R. O'Neill,O. P. van Diggelen,Milan Elleder,Marc C. Patterson,Roscoe O. Brady,Marie T. Vanier,Peter G. Pentchev,Danilo A. Tagle +37 more
TL;DR: Transfection of NP-C fibroblasts with wild-type NPC1 cDNA resulted in correction of their excessive lysosomal storage of LDL cholesterol, thereby defining the critical role of NPC1 in regulation of intracellular cholesterol trafficking.
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Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
Estela Area-Gomez,Maria del Carmen Lara Castillo,Marc D Tambini,Cristina Guardia-Laguarta,Ad J. C. de Groof,Ad J. C. de Groof,Moneek Madra,Junichi Ikenouchi,Masato Umeda,Thomas D. Bird,Stephen L. Sturley,Eric A. Schon +11 more
TL;DR: It is proposed that upregulated MAM function at the ER–mitochondrial interface, and increased cross‐talk between these two organelles, may play a hitherto unrecognized role in the pathogenesis of AD.
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Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes
TL;DR: It is speculated that ARGP1 participates in the coenzyme A-dependent acylation of substrate(s) other than cholesterol, and unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylations in triglyceride biosynthesis.
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The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast
TL;DR: It is shown here that DGA1, the sole member of this gene family in yeast, has a physiological role in triglyceride synthesis, and three enzymes can account for diacylglycerol esterification in yeast.
Journal ArticleDOI
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.
Tilla S. Worgall,Tilla S. Worgall,Stephen L. Sturley,Toru Seo,Toru Seo,Timothy F. Osborne,Richard J. Deckelbaum,Richard J. Deckelbaum +7 more
TL;DR: It is hypothesized that unsaturated fatty acids increase intracellular regulatory pools of cholesterol and thus affect mature SREBP levels and expression of SRE-dependent genes and oleate decreased levels of the mature sterol regulatory element-binding proteins S REBP-1 and -2 and HMG-CoA synthase mRNA.