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Stephen L. Sturley

Researcher at Columbia University Medical Center

Publications -  92
Citations -  7889

Stephen L. Sturley is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Saccharomyces cerevisiae & Sterol O-acyltransferase. The author has an hindex of 42, co-authored 90 publications receiving 7400 citations. Previous affiliations of Stephen L. Sturley include University of Wisconsin-Madison & New York University.

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Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

TL;DR: It is proposed that upregulated MAM function at the ER–mitochondrial interface, and increased cross‐talk between these two organelles, may play a hitherto unrecognized role in the pathogenesis of AD.
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Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes

TL;DR: It is speculated that ARGP1 participates in the coenzyme A-dependent acylation of substrate(s) other than cholesterol, and unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylations in triglyceride biosynthesis.
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The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast

TL;DR: It is shown here that DGA1, the sole member of this gene family in yeast, has a physiological role in triglyceride synthesis, and three enzymes can account for diacylglycerol esterification in yeast.
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Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.

TL;DR: It is hypothesized that unsaturated fatty acids increase intracellular regulatory pools of cholesterol and thus affect mature SREBP levels and expression of SRE-dependent genes and oleate decreased levels of the mature sterol regulatory element-binding proteins S REBP-1 and -2 and HMG-CoA synthase mRNA.