M
Masayuki Orimo
Researcher at Chiba University
Publications - 6
Citations - 2147
Masayuki Orimo is an academic researcher from Chiba University. The author has contributed to research in topics: Senescence & Vascular endothelial growth factor C. The author has an hindex of 6, co-authored 6 publications receiving 1911 citations. Previous affiliations of Masayuki Orimo include Kanazawa University.
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Journal ArticleDOI
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Masanori Sano,Tohru Minamino,Haruhiro Toko,Hideyuki Miyauchi,Masayuki Orimo,Yingjie Qin,Hiroshi Akazawa,Kaoru Tateno,Yosuke Kayama,Mutsuo Harada,Ippei Shimizu,Takayuki Asahara,Hirofumi Hamada,Shuhei Tomita,Jeffrey D. Molkentin,Yunzeng Zou,Issei Komuro +16 more
TL;DR: It is shown that cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiachypertrophy and that p53 accumulation is essential for the transition from cardiac hypertrophy to heart failure and that the anti-angiogenic property of p53 may have a crucial function in the transition.
Journal ArticleDOI
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Tohru Minamino,Tohru Minamino,Masayuki Orimo,Ippei Shimizu,Takeshige Kunieda,Masataka Yokoyama,Takashi Ito,Aika Nojima,Akira Nabetani,Yuichi Oike,Yuichi Oike,Hisahiro Matsubara,Fuyuki Ishikawa,Issei Komuro,Issei Komuro +14 more
TL;DR: It is shown that p53 expression in adipose tissue is crucially involved in the development of insulin resistance, which underlies age-related cardiovascular and metabolic disorders and suggests that cellular aging signals in adipOSE tissue could be a new target for the treatment of diabetes.
Journal ArticleDOI
Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p21-Dependent Pathway
Takeshige Kunieda,Tohru Minamino,Jun-ichiro Nishi,Kaoru Tateno,Tomomi Oyama,Taro Katsuno,Hideyuki Miyauchi,Masayuki Orimo,Sho Okada,Masayuki Takamura,Toshio Nagai,Shuichi Kaneko,Issei Komuro +12 more
TL;DR: The results suggest a critical role of p21-dependent premature senescence of VSMCs in the pathogenesis of atherosclerosis, and demonstrate that Ang II promotes vascular inflammation by inducing premature senesence ofVSMCs both in vitro and in vivo.
Journal ArticleDOI
Protective Role of SIRT1 in Diabetic Vascular Dysfunction
Masayuki Orimo,Tohru Minamino,Hideyuki Miyauchi,Kaoru Tateno,Sho Okada,Junji Moriya,Issei Komuro +6 more
TL;DR: These findings represent a novel mechanism of vascular cell senescence induced by hyperglycemia and suggest a protective role of SIRT1 in the pathogenesis of diabetic vasculopathy.
Journal ArticleDOI
Cellular Senescence Impairs Circadian Expression of Clock Genes In Vitro and In Vivo
Takeshige Kunieda,Tohru Minamino,Taro Katsuno,Kaoru Tateno,Jun-ichiro Nishi,Hideyuki Miyauchi,Masayuki Orimo,Sho Okada,Issei Komuro +8 more
TL;DR: The results suggest that senescence decreases the ability of cells to transmit circadian signals to their clocks and that regulation of clock gene expression may be a novel strategy for the treatment of age-associated impairment of circadian rhythmicity.