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Masataka Yokoyama
Researcher at Chiba University
Publications - 14
Citations - 1647
Masataka Yokoyama is an academic researcher from Chiba University. The author has contributed to research in topics: Downregulation and upregulation & Inflammation. The author has an hindex of 12, co-authored 13 publications receiving 1371 citations.
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Journal ArticleDOI
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Tohru Minamino,Tohru Minamino,Masayuki Orimo,Ippei Shimizu,Takeshige Kunieda,Masataka Yokoyama,Takashi Ito,Aika Nojima,Akira Nabetani,Yuichi Oike,Yuichi Oike,Hisahiro Matsubara,Fuyuki Ishikawa,Issei Komuro,Issei Komuro +14 more
TL;DR: It is shown that p53 expression in adipose tissue is crucially involved in the development of insulin resistance, which underlies age-related cardiovascular and metabolic disorders and suggests that cellular aging signals in adipOSE tissue could be a new target for the treatment of diabetes.
Journal ArticleDOI
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents
Ippei Shimizu,Tohru Minamino,Haruhiro Toko,Sho Okada,Hiroyuki Ikeda,Noritaka Yasuda,Kaoru Tateno,Junji Moriya,Masataka Yokoyama,Aika Nojima,Gou Young Koh,Hiroshi Akazawa,Ichiro Shiojima,C. Ronald Kahn,E. Dale Abel,Issei Komuro +15 more
TL;DR: It is suggested that the use of insulin to control hyperglycemia could be harmful in the setting of pressure overload and that modulation of insulin signaling is crucial for the treatment of HF.
Journal ArticleDOI
p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure
Ippei Shimizu,Yohko Yoshida,Taro Katsuno,Kaoru Tateno,Sho Okada,Junji Moriya,Masataka Yokoyama,Aika Nojima,Takashi Ito,Rudolf Zechner,Issei Komuro,Yoshio Kobayashi,Tohru Minamino,Tohru Minamino +13 more
TL;DR: The results indicate that chronic pressure overload upregulates adipose tissue p53 by promoting lipolysis via the sympathetic nervous system, leading to an inflammatory response of adipOSE tissue and insulin resistance.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor Protects Against Cardiac Dysfunction After Myocardial Infarction via a Central Nervous System–Mediated Pathway
Sho Okada,Masataka Yokoyama,Haruhiro Toko,Kaoru Tateno,Junji Moriya,Ippei Shimizu,Aika Nojima,Takashi U. Ito,Yohko Yoshida,Yoshio Kobayashi,Hideki Katagiri,Tohru Minamino,Issei Komuro +12 more
TL;DR: It is suggested that BDNF expression is upregulated by neural signals from the heart after MI and then protects the myocardium against ischemic injury.
Journal ArticleDOI
Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure
Yosuke Kayama,Tohru Minamino,Tohru Minamino,Haruhiro Toko,Masaya Sakamoto,Ippei Shimizu,Hidehisa Takahashi,Sho Okada,Kaoru Tateno,Junji Moriya,Masataka Yokoyama,Aika Nojima,Michihiro Yoshimura,Kensuke Egashira,Hiroyuki Aburatani,Issei Komuro +15 more
TL;DR: The results suggest that cardiac 12/15-LOX is involved in the development of heart failure and that inhibition of 12-hydroxy-eicosatetraenoic acid could be a novel treatment for this condition.