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Ippei Shimizu
Researcher at Niigata University
Publications - 72
Citations - 5422
Ippei Shimizu is an academic researcher from Niigata University. The author has contributed to research in topics: Adipose tissue & Heart failure. The author has an hindex of 27, co-authored 57 publications receiving 4286 citations. Previous affiliations of Ippei Shimizu include Boston University & Chiba University.
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Journal ArticleDOI
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Masanori Sano,Tohru Minamino,Haruhiro Toko,Hideyuki Miyauchi,Masayuki Orimo,Yingjie Qin,Hiroshi Akazawa,Kaoru Tateno,Yosuke Kayama,Mutsuo Harada,Ippei Shimizu,Takayuki Asahara,Hirofumi Hamada,Shuhei Tomita,Jeffrey D. Molkentin,Yunzeng Zou,Issei Komuro +16 more
TL;DR: It is shown that cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiachypertrophy and that p53 accumulation is essential for the transition from cardiac hypertrophy to heart failure and that the anti-angiogenic property of p53 may have a crucial function in the transition.
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A crucial role for adipose tissue p53 in the regulation of insulin resistance
Tohru Minamino,Tohru Minamino,Masayuki Orimo,Ippei Shimizu,Takeshige Kunieda,Masataka Yokoyama,Takashi Ito,Aika Nojima,Akira Nabetani,Yuichi Oike,Yuichi Oike,Hisahiro Matsubara,Fuyuki Ishikawa,Issei Komuro,Issei Komuro +14 more
TL;DR: It is shown that p53 expression in adipose tissue is crucially involved in the development of insulin resistance, which underlies age-related cardiovascular and metabolic disorders and suggests that cellular aging signals in adipOSE tissue could be a new target for the treatment of diabetes.
Journal ArticleDOI
Physiological and pathological cardiac hypertrophy
Ippei Shimizu,Tohru Minamino +1 more
TL;DR: The key molecules and cellular responses involved in physiological/pathological cardiac hypertrophy are described, which lead to maladaptive cardiac remodeling and heart failure.
Journal ArticleDOI
Vascular rarefaction mediates whitening of brown fat in obesity
Ippei Shimizu,Tamar Aprahamian,Ryosuke Kikuchi,Ayako Shimizu,Kyriakos N. Papanicolaou,Susan MacLauchlan,Sonomi Maruyama,Kenneth Walsh +7 more
TL;DR: Using a murine model of diet-induced obesity, it is determined that obesity causes capillary rarefaction and functional hypoxia in BAT, leading to a BAT "whitening" phenotype that is characterized by mitochondrial dysfunction, lipid droplet accumulation, and decreased expression of Vegfa.
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Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Atsuhiko T. Naito,Tomokazu Sumida,Seitaro Nomura,Mei-Lan Liu,Tomoaki Higo,Akito Nakagawa,Katsuki Okada,Taku Sakai,Akihito Hashimoto,Yurina Hara,Ippei Shimizu,Weidong Zhu,Haruhiro Toko,Akemi Katada,Hiroshi Akazawa,Toru Oka,Jong-Kook Lee,Tohru Minamino,Toshio Nagai,Kenneth Walsh,Akira Kikuchi,Misako Matsumoto,Marina Botto,Ichiro Shiojima,Issei Komuro,Issei Komuro +25 more
TL;DR: It is reported that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration and suggest the unexpected role of complement C 1q in Wnt signal transduction and modulation of mammalian aging.