M
Massimo Tonacchera
Researcher at University of Pisa
Publications - 171
Citations - 5632
Massimo Tonacchera is an academic researcher from University of Pisa. The author has contributed to research in topics: Thyroid & Receptor. The author has an hindex of 42, co-authored 160 publications receiving 5230 citations. Previous affiliations of Massimo Tonacchera include Université libre de Bruxelles & University of Calabria.
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Journal ArticleDOI
Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter.
Massimo Tonacchera,Aldo Pinchera,Antonio Dimida,E. Ferrarini,Patrizia Agretti,Paolo Vitti,Ferruccio Santini,Kenny S. Crump,John P. Gibbs +8 more
TL;DR: Results are consistent with a common mode of action by these anions of simple competitive interaction, in which a concentration of any one of ClO(4) (-) SCN(-), and NO(3) (-), occurring either individually or as part of a mixture of the three anions, is indistinguishable from a concentration or dilution of either of the remaining two ions in inhibiting iodine uptake at the NIS.
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Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.
Jasmine Parma,J. Van Sande,Stéphane Swillens,Massimo Tonacchera,Jacques Emile Dumont,Gilbert Vassart +5 more
TL;DR: The results demonstrate that 1) the first and second extracellular loops contribute to the silencing of the unliganded TSH receptor; 2) the two regulatory cascades normally under TSH control can be constitutively activated by somatic mutations of the receptor.
Journal ArticleDOI
Somatic and germline mutations of the TSH receptor gene in thyroid diseases.
J. Van Sande,Jasmine Parma,Massimo Tonacchera,Stéphane Swillens,Jacques Emile Dumont,Gilbert Vassart +5 more
TL;DR: The present review will summarize recent findings identifying mutations of the TSH receptor gene as a cause for thyroid diseases.
Journal ArticleDOI
Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease.
Paola Romagnani,Mario Rotondi,Elena Lazzeri,Laura Lasagni,Michela Francalanci,Andrea Buonamano,Stefano Milani,Paolo Vitti,Luca Chiovato,Massimo Tonacchera,Antonio Bellastella,Mario Serio +11 more
TL;DR: The results of this study demonstrate that the CXCR3-binding chemokines IP-10/CXCL10 and Mig/CxCL9 play an important role in the recruitment of cells and in the amplification of inflammation in Graves' disease, and suggest that the production of these chemokine by resident follicular epithelial cells may contribute to the recruited CX CR3-expressing type 1 T-helper cells in the initial phases of GD.
Journal ArticleDOI
Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia.
Massimo Tonacchera,J. Van Sande,Filomena Cetani,Stéphane Swillens,Claire Schvartz,P Winiszewski,L Portmann,Jacques Emile Dumont,Gilbert Vassart,Jasmine Parma +9 more
TL;DR: The differential effects of individual mutations on stimulation by bTSH of cAMP or IP accumulation suggest that individual mutant receptors may achieve different active conformations with selective abilities to couple to Gs alpha and to Gq alpha.