Mathura P. Ramanathan

TL;DR: It is shown that in the partial, but not total, absence of CD4+ T cell help, plasmid-delivered IL-15 could restore CD8 secondary immune responses to an antigenic DNA plasmids, supporting the idea that the effects ofIL-15 on CD8+ Tcell expansion require the presence of low levels of CD 4 T cells.

TL;DR: It is reported that the WNV-capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture, demonstrating that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.

TL;DR: A DNA vaccine encoding the WNV capsid protein was constructed, and the in vivo immune responses generated were investigated in DNA vaccine-immunized mice, supporting the potential utility of this method as a tool for developing immunization strategies for WNV and other emerging pathogens.

TL;DR: A novel-engineered DNA vaccine that encodes a HPV-16 consensus E6/E7 fusion gene (pConE6E7) with the goal of increasing its antitumor cellular immunity, which resulted in 100% protection against HPV E6 and E7-expressing tumors.

TL;DR: Epitope mapping results indicated that there is an increase in the breadth and magnitude of cross-reactive cellular responses induced by the EY2E1-B immunogen, which suggest that such a synthetic immunogen deserves further examination for its potential to serve as a component antigen in an HIV vaccine cocktail.