M
Michele A. Kutzler
Researcher at Drexel University
Publications - 85
Citations - 2949
Michele A. Kutzler is an academic researcher from Drexel University. The author has contributed to research in topics: Immune system & DNA vaccination. The author has an hindex of 25, co-authored 68 publications receiving 2712 citations. Previous affiliations of Michele A. Kutzler include Temple University & University of Pennsylvania.
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Journal ArticleDOI
DNA vaccines: ready for prime time?
TL;DR: A productive future for DNA vaccine technology is suggested as more optimized constructs, better trial designs and improved platforms are being brought into the clinic.
Journal ArticleDOI
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.
Michele A. Kutzler,Tara M. Robinson,Michael A. Chattergoon,Daniel K. Choo,Andrew Y. Choo,Philip Y. Choe,Mathura P. Ramanathan,Rose Parkinson,Sagar B. Kudchodkar,Yutaka Tamura,Maninder K. Sidhu,Vidia Roopchand,J. Joseph Kim,George N. Pavlakis,Barbara K. Felber,Thomas A. Waldmann,Jean D. Boyer,David B. Weiner +17 more
TL;DR: It is shown that in the partial, but not total, absence of CD4+ T cell help, plasmid-delivered IL-15 could restore CD8 secondary immune responses to an antigenic DNA plasmids, supporting the idea that the effects ofIL-15 on CD8+ Tcell expansion require the presence of low levels of CD 4 T cells.
Journal ArticleDOI
Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens
Dominick Laddy,Jian Yan,Michele A. Kutzler,Darwyn Kobasa,Gary P. Kobinger,Gary P. Kobinger,Amir S. Khan,Jack Greenhouse,Niranjan Y. Sardesai,Ruxandra Draghia-Akli,David B. Weiner +10 more
TL;DR: The ability of these antigens to protect from both morbidity and mortality in a ferret model of HPAI, in both the presence and absence of neutralizing antibody, will be critical in responding to the antigenic drift that will likely occur before these viruses cross the species barrier to humans.
Journal ArticleDOI
Developing DNA vaccines that call to dendritic cells
TL;DR: A new study reports the synergistic recruitment, expansion, and activation of DCs in vivo in a mouse model through covaccination with plasmids encoding macrophage inflammatory protein-1alpha, fms-like tyrosine kinase 3 ligand, and the DNA vaccine.
Journal ArticleDOI
SIV DNA vaccine co‐administered with IL‐12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques
Jean D. Boyer,Tara M. Robinson,Michele A. Kutzler,Rose Parkinson,Sandra A. Calarota,Maninder K. Sidhu,Karuppiah Muthumani,Mark G. Lewis,George N. Pavlakis,Barbara K. Felber,David B. Weiner +10 more
TL;DR: Current evidence suggests that a strong induced CD8 human immunodeficiency virus type 1 (HIV‐1)‐specific cell mediated immune response may be an important aspect of an HIV vaccine, and adjuvanted DNA vaccines illustrate that IL‐12 enhances a CD8 vaccine immune response, however, different cellular profiles.