M
Matt Parsek
Researcher at University of Washington
Publications - 2
Citations - 452
Matt Parsek is an academic researcher from University of Washington. The author has contributed to research in topics: Pseudomonas aeruginosa & Quorum sensing. The author has an hindex of 2, co-authored 2 publications receiving 389 citations.
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Journal ArticleDOI
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Morten Alhede,Kasper Nørskov Kragh,Klaus Qvortrup,Marie Allesen-Holm,Maria van Gennip,Louise Dahl Christensen,Peter Østrup Jensen,Anne K. Nielsen,Matt Parsek,Daniel J. Wozniak,Søren Molin,Tim Tolker-Nielsen,Niels Høiby,Michael Givskov,Thomas Bjarnsholt,Thomas Bjarnsholt +15 more
TL;DR: The data indicate that the tolerance of both biofilms and non-attached aggregates towards antibiotics is reversible by physical disruption, and provides evidence that the antibiotic tolerance is likely to be dependent on both the physiological states of the aggregates and particular matrix components.
Journal ArticleDOI
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.
Morten Alhede,Morten Alhede,Thomas Bjarnsholt,Peter Østrup Jensen,Richard Kerry Phipps,Claus Moser,Lars Christophersen,Louise Dahl Christensen,Maria van Gennip,Matt Parsek,Niels Høiby,Thomas Bovbjerg Rasmussen,Michael Givskov +12 more
TL;DR: In vitro and in vivo analyses support a 'launch a shield' model by which rhamnolipids surround the biofilm bacteria and on contact eliminate incoming PMNs, and strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence.