M
Morten Alhede
Researcher at University of Copenhagen
Publications - 37
Citations - 3779
Morten Alhede is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Pseudomonas aeruginosa & Biofilm. The author has an hindex of 24, co-authored 37 publications receiving 3190 citations. Previous affiliations of Morten Alhede include Technical University of Denmark & Copenhagen University Hospital.
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Journal ArticleDOI
The in vivo biofilm
Thomas Bjarnsholt,Thomas Bjarnsholt,Maria Alhede,Morten Alhede,Morten Alhede,Steffen Robert Eickhardt-Sørensen,Claus Moser,Michael Kühl,Michael Kühl,Michael Kühl,Peter Østrup Jensen,Niels Høiby,Niels Høiby +12 more
TL;DR: Why the current in vitro models of biofilms might be limited for describing infectious biofilmms are discussed, and new strategies for improving this discrepancy are suggested.
Journal ArticleDOI
Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing
Tim Holm Jakobsen,Maria van Gennip,Richard Kerry Phipps,Meenakshi Sundaram Shanmugham,Louise Dahl Christensen,Morten Alhede,Mette Eline Skindersoe,Thomas Bovbjerg Rasmussen,Karlheinz Friedrich,Friedrich Uthe,Peter Østrup Jensen,Claus Moser,Kristian Fog Nielsen,Leo Eberl,Thomas Ostenfeld Larsen,David Tanner,Niels Høiby,Thomas Bjarnsholt,Michael Givskov,Michael Givskov +19 more
TL;DR: Quorum sensing (QS), a communication system used by pathogenic bacteria like Pseudomonas aeruginosa to synchronize the expression of specific genes involved in pathogenicity, is a possible drug target and ajoene, a sulfur-containing compound with potential as an antipathogenic drug is determined.
Journal ArticleDOI
Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa
Mette E. Skindersoe,Morten Alhede,Richard Kerry Phipps,Liang Yang,Peter Østrup Jensen,Thomas Bovbjerg Rasmussen,Thomas Bjarnsholt,Tim Tolker-Nielsen,Niels Høiby,Michael Givskov +9 more
TL;DR: Results from the virulence factor assays, reverse transcription-PCR, and the DNA microarrays support the finding that AZM, CFT, and CPR decrease the expression of a range of QS-regulated virulence factors, suggesting the underlying mechanism may be mediated by changes in membrane permeability.
Journal ArticleDOI
Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Morten Alhede,Kasper Nørskov Kragh,Klaus Qvortrup,Marie Allesen-Holm,Maria van Gennip,Louise Dahl Christensen,Peter Østrup Jensen,Anne K. Nielsen,Matt Parsek,Daniel J. Wozniak,Søren Molin,Tim Tolker-Nielsen,Niels Høiby,Michael Givskov,Thomas Bjarnsholt,Thomas Bjarnsholt +15 more
TL;DR: The data indicate that the tolerance of both biofilms and non-attached aggregates towards antibiotics is reversible by physical disruption, and provides evidence that the antibiotic tolerance is likely to be dependent on both the physiological states of the aggregates and particular matrix components.
Journal ArticleDOI
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.
Morten Alhede,Morten Alhede,Thomas Bjarnsholt,Peter Østrup Jensen,Richard Kerry Phipps,Claus Moser,Lars Christophersen,Louise Dahl Christensen,Maria van Gennip,Matt Parsek,Niels Høiby,Thomas Bovbjerg Rasmussen,Michael Givskov +12 more
TL;DR: In vitro and in vivo analyses support a 'launch a shield' model by which rhamnolipids surround the biofilm bacteria and on contact eliminate incoming PMNs, and strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence.