Thomas Bovbjerg Rasmussen

TL;DR: Results from the virulence factor assays, reverse transcription-PCR, and the DNA microarrays support the finding that AZM, CFT, and CPR decrease the expression of a range of QS-regulated virulence factors, suggesting the underlying mechanism may be mediated by changes in membrane permeability.

TL;DR: In vitro and in vivo analyses support a 'launch a shield' model by which rhamnolipids surround the biofilm bacteria and on contact eliminate incoming PMNs, and strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence.

TL;DR: In this study, an in silico analysis combining a stochastic data mining method, analysis of homologous gene distribution and the identification of features frequently associated with horizontally transferred genes to assess the proportion of the S. thermophilus genome that could originate from HGT is described.

TL;DR: A recent transcriptomic analysis strongly suggests that the wild-type Pseudomonas aeruginosa further activates a QS-controlled strategic defense system, which reacts upon the encounter with polymorphonuclear leukocytes (PMNs) and suppresses the powerful cellular immune response by paralyzing the PMNs.

TL;DR: This chapter describes the molecular mechanisms of quorum sensing in Gram-negative and gram positive bacteria, and QS in a biofilm, leading to what is described in subsequent chapters that QS is a highly attractive target for therapy against biofilm chronic infections.